Precision Aerosol Therapy Through AI and flexiVent-Controlled Delivery

Yang, L., et al (2024) introduces LungVis 1.0, an AI-driven imaging platform integrating light sheet fluorescence microscopy (LSFM) and deep learning for mapping nanoparticle (NP) deposition across murine lungs. The research highlights the advantages of aerosol-based delivery methods over traditional liquid-based approaches, emphasizing the uniformity of NP deposition in distal alveolar regions achieved via ventilator-assisted aerosol delivery (VAAD). The flexiVent FX system plays a critical role in this process, enabling precise, controlled aerosol delivery for enhanced deposition and clinical relevance. The findings redefine our understanding of lung macrophage dynamics, revealing their active role in NP redistribution, challenging traditional views of their static nature.