The Impact of Landscape Fire Smoke On Respiratory and Cardiac Health
The incidence of landscape fires has been rising globally, leading to increased exposure to landscape fire smoke (LFS) among millions of people. The inhalation of particulate matter (PM) from LFS is associated with adverse respiratory and cardiovascular outcomes. However, the mechanisms by which LFS impacts these functions remain inadequately understood. This blog focuses on a new publication from Gomez et al (2024) on how LFS exposure impairs respiratory and cardiac health, with a special focus on the role of the flexiVent system in measuring the respiratory function effects.
Respiratory Impact:
- Increased Airway Hyperresponsiveness (AHR) as measured by the flexiVent: Both short-term (3 days) and long-term (14 days) exposure to LFS PM10 increased airway hyperresponsiveness in mice. This was evident from methacholine-induced AHR tests, which showed heightened sensitivity in the airways.
- Steroid Insensitivity in Asthma: LFS exposure induced steroid insensitivity in experimental asthma, suggesting that typical asthma treatments might be less effective during periods of high LFS exposure.
- Gas Exchange Impairment: Long-term exposure to LFS PM10 significantly decreased the diffusing factor of the lung for carbon monoxide (DFCO), indicating impaired gas exchange.
- Inflammatory Response: Interestingly, the adverse effects on lung function occurred independently of significant changes in airway inflammation, highlighting the complex nature of LFS-induced respiratory issues.
Cardiac Impact:
- Decreased Cardiac Function: Short-term exposure to LFS PM10 resulted in reduced cardiac function, as evidenced by decreased left ventricular ejection fraction and fractional shortening in mice.
- Gene Expression Changes: LFS exposure altered the expression of genes related to oxidative stress and cardiovascular pathologies, pointing towards a molecular basis for the observed cardiac dysfunction.
The detrimental effects of LFS on respiratory and cardiac function underscore the urgent need for strategies to mitigate exposure and improve public health responses during landscape fire events. The use of advanced tools like the flexiVent system is invaluable in research, offering precise measurements that enhance our understanding of the physiological impacts of LFS. As landscape fires become more frequent, ongoing research and technological advancements will be crucial in developing effective interventions to protect vulnerable populations from the harmful effects of LFS.
Gomez, H., et al. (2024). Landscape fire smoke airway exposure impairs respiratory and cardiac function and worsens experimental asthma. Environmental and Occupational Disease, 154(1): P209-221