Pre-Clinical Articles
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Novel Biomarkers May Help Predict the Susceptibility of a Population to Rheumatoid Arthritis
Genetics (i.e., mutations) are considered to be the main factor predisposing to the etiology of rheumatoid arthritis (RA), but they account for only a few changes in RA disease risk, and in contrast to genetics, the environment may have an important impact on epigenetic properties associated with disease etiology. Recently, in a study published in the journal Scientific Reports entitled ...
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The Structure of Key Proteins in Parkinson`s Disease Solved
Australian researchers have recently solved a multi-year mystery about Parkinson's disease. They solved the structure of a key protein that is expected to rapidly treat this incurable disease. The findings appear in Nature. For the first time, the researchers took a "live" shot of a protein called PINK1. The findings explain how this protein is activated in cells, thereby initiating the ...
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Research Progress of Targeted Protein Degradation Technology
The mode of action of currently developed drugs is mostly to achieve the purpose of disease treatment by inhibiting or enhancing the activity of target proteins. However, these drugs have to bind to the active site of target proteins to work. Among the known drug target proteins, only about 20% of the target proteins contain bindable active site, and 80% of the target proteins are non-druggable ...
By Profacgen
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Some Basic Facts about Active Pharmaceutical Ingredient Excipients for Drug Discovery
Pharmaceutical excipients are substances formulated together with active pharmaceutical ingredients (APIs) of the drug, and excipients account for most of the drug composition. Excipients are designed to interact with and enhance the properties of APIs. Excipients have various functions. In addition to acting as carriers, and improving stability, pharmaceutical excipients are also conducive in ...
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The Effects of Excipients on Pharmaceutical Preparations in Drug Design
Excipients are very important for pharmaceutical preparations. It can be said that without excipients, there will be no pharmaceutical preparations, let alone different pharmaceutical dosage forms such as powders, granules, tablets, oral liquids or injections. When the drug and the appropriate excipients are combined into a specific dosage form, the drug would become safer, more stable and more ...
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Hospital and Health Care - Case Study
Hospitals need to be situated at the most convenient location available. Toxic pollution surrounding the hospital can be a heightened health risk for its patients. The hospital needs to ensure that its infrastructure shields its patients from these possible health risks. Prkruti can be a helpful tool to monitor the pollution levels so that necessary action can be taken as and when ...
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Science: Blocking fibrin holds promise for the treatment of periodontal disease
In a new study, researchers from the National Institute of Dental Craniofacial Research (NIDCR) have found that blocking the function of a coagulation protein prevents bone loss caused by periodontal (gingival) disease in mice. According to animal and human data, they found that the accumulation of this clotting protein called fibrin triggers an excessive immune response that damages the gingiva ...
By Matexcel
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New Drug Discovery Tool that Can Screen More Than 11 Billion Compounds Found
There are docking stations called receptors on the surface of our cells. Various compounds ranging from caffeine and dopamine to heroin, tetrahydrocannabinol (THC) and lysergic diethylamine (LSD) all bind to these receptors. Indeed, G protein-coupled receptors are the intended target of action for more than 30% of drugs currently on the market. But these drugs often also target unintended targets ...
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The Effects of Excipients on Pharmaceutical Preparation
Excipients are very important for pharmaceutical preparations. It can be said that without excipients, there will be no pharmaceutical preparations, let alone different pharmaceutical dosage forms such as powders, granules, tablets, oral liquids or injections. When the drug and the appropriate excipients are combined into a specific dosage form, the drug would become safer, more stable and more ...
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Detailed Introduction to Steroids Analysis
Steroid hormone is a class of compounds that contain cyclopentane polyhydrophenanthrene structure formed by cholesterol and catalyzed by cytochrome P450 enzymes. Steroid hormones mainly include adrenocorticotropic hormones secreted by the adrenal cortex and sex hormones secreted by the gonads, which are mainly divided into four categories: progesterone, corticosteroid, estrogen and androgen. ...
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Integrating Synthetic Accessibility with AI-based Generative Drug Design
Abstract Generative models are frequently used for de novo design in drug discovery projects to propose new molecules. However, the question of whether or not the generated molecules can be synthesized is not systematically taken into account during generation, even though being able to synthesize the generated molecules is a fundamental requirement for such methods to be useful in practice. ...
By Iktos
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iTRAQ: A Proteomics Research Tool
Proteomics is a combination of two words: protein and genomics. Proteomics studies all the proteins expressed by a cell or even an organism. Essentially, it is the study of proteins and their characteristics on a large scale, including protein expression levels, post-translational modifications, and protein-protein interactions. Various relevant information can be obtained for an overall and ...
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The Mode of Action of Basic Proteins Involved in Cancer and Alzheimer's Disease Found
These proteins belonging to the HAT family are essential for life because they transport amino acids to the cell membrane. Although members of the family are nearly identical, they selectively transport certain amino acids. This specificity determines their involvement in specific functions, such as cell growth or neuronal function, and consequently in related diseases, such as cancer or ...
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Structural Characteristics and Functions of Glycoproteins, Proteoglycans and Glycolipids
Sugar is an important nutrient for the human body, and its primary physiological function is to provide energy and carbon sources for life activities. In addition, sugar also participates in the composition of glycoproteins and glycolipids, and regulates cell information transmission. Monosaccharides are polymerized by glycosidic bonds to form oligosaccharides or polysaccharides, also called ...
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High prevalence of psychological distress among healthcare workers during pandemic
Doctors more likely to experience depression while anxiety more common among Nurses A study by a team of researchers from the University of Wollongong (UOW), St George Hospital and the Illawarra Health and Medical Research Institute (IHMRI) has found a high prevalence of anxiety and depression among healthcare workers around the world during the COVID-19 pandemic. The researchers found that ...
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Addressing Medical Negligence: Is It More Common than We Think?
It may surprise you to learn that the third most common cause of death in the U.S. is reputed to be medical negligence. The figures vary on the actual average number of deaths due to medical negligence each year. A John Hopkins study put the number at approximately 250,000 but other sources suggest it’s over 400,000 cases annually. The situation is so dire that the doctors involved with ...
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Science: Knockout of this epigenetic gene gives CAR-T cells the ability to continuously attack cancer cells
Simply put, CAR-T is to transform the patient's immune T cells in vitro by biotechnology, so that they recognize antigens on the surface of tumor cells, and then inject these cells back into the patient to achieve the therapeutic effect of recognizing and killing cancer cells. In 2017, CAR-T therapy was first approved by the FDA for the treatment of blood cancers such as leukemia and lymphoma. ...
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Metabolomics in Gut Microbiota Research
With rapid development in sequencing technology, researchers can better assess the effect of the gut microbiome on human health. Human beings have a symbiotic relationship with the microbiota since birth. The environment, proximity to other humans and animals, diet, genetics, and time changes can all affect the microbial composition of our skin, mouth, and intestines. Compared with other ...
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Comprehensive protein interaction network helps discover candidate drugs for the treatment of COVID-19
Treatment options for COVID-19 remain limited. Researchers at the University of Helsinki and the University of Eastern Finland first searched for appropriate drug targets and reusable drugs and finally discovered six candidates with antiviral effects against SARS-CoV-2. Understanding viral pathogenesis at the molecular level is key to the development of effective therapies for COVID-19. The ...
By Profacgen
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Targeted Therapy of Intracellular Oncoproteins by Peptide-centered CAR T Cells
Researchers at the Children's Hospital of Philadelphia (CHOP) have made a breakthrough in the treatment of aggressive solid cancers, and they have developed a new cancer treatment that targets proteins within tumor cells that are essential for tumor growth and survival, but this has not been possible before. Using the power of large data and advanced computational methods, researchers can ...
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