Pre-Clinical Articles | Medical XPRT

Why Choose Oligonucleotide Products and Services from BOC RNA?

DNA (deoxyribonucleic acid) and RNA (ribonucleic acid) are essential for all known forms of life. They are the main information-carrying molecules in the cell and constitute the genetic material. DNA is similar to RNA and uses a slightly different set of nucleobases. Nucleobases are also known as bases or nitrogenous bases. Nucleobases are electron-rich heterocyclic aromatic that may also ...

Sep. 14, 2021

By BOC Sciences

Gene of the Week: NQO1 (Skin Renewal)

There are around 30,000 genes in the human genome. In this weekly series, we’ll write about a new gene featured in Orig3n DNA tests, so you can discover the kinds of information genetic assessments can offer you. Have you ever wondered how or why your skin appears to be more or less youthful with the passing years? There’s a gene for that™! Spring is on the way, and you know ...

Aug. 31, 2021

By Orig3n

Global ADC Drug Overview

In recent years, antibody-drug conjugates (ADCs) have been widely sought after due to their excellent clinical performance and market returns. ADC drugs are composed of three parts: antibody, effector molecule (Payload, usually cytotoxic agent) and linker. Compared with traditional drugs, ADC drugs have obvious advantages in improving targeting and reducing side effects. 1. Global ADC listing ...

Aug. 28, 2021

By BOC Sciences

mRNA Delivery System

RNA is a hydrophilic, negatively charged macromolecule, and its ability to autonomously transmembrane is limited. Therefore, how to efficiently deliver mRNA to the cytoplasm and play a corresponding role is one of the key issues that limit the application of RNA therapy. The wide range of applications of therapeutic mRNA requires efficient and safe delivery methods. An ideal delivery system ...

Aug. 27, 2021

By BOC Sciences

The Reality and Future of Peptide Drugs

It has been said that the 21st century is the century of peptide drugs, and the fate of this substance, which lies between a large protein and a small molecule compound, is bound to be extraordinary. What are peptide drugs? Peptides are a class of compounds made up of amino acids linked by peptide bonds and are chemically active substances commonly found in living organisms. According to the ...

Aug. 24, 2021

By Creative Peptides

Answers to Frequently Asked Questions Regarding Gene Ontology and GO Enrichment Analysis

"Big data", "omics", and "data mining" are vocabulary we have often heard in recent years, and second-generation sequencing is often used in scientific research. No matter which sequencing company performs sequencing or data analysis, a standard analysis method will be seen in the final report: functional enrichment analysis. Given that most people know little about this analysis method, we have ...

Aug. 12, 2021

By CD ComputaBio

CRISPR Screening Technology Brings More Versatility to High-Throughput Sequencing

Introduction to CRISPR Screen Sequencing CRISPR Screen technology is used for high-throughput screening, allowing a large number of gene mutant cells to be created and a mutant cell library to be screened in various external environments. The relationship between phenotype and genotype can be further evaluated using high-throughput sequencing and bioinformatics analysis. Furthermore, ...

Aug. 12, 2021

By CD Genomics

Structure-based Design of Protein Kinase Inhibitors

Protein kinases are effective anti-cancer drug targets that have been proven in many experiments and facts. Many small molecule protein kinase inhibitors approved by the FDA can be used for cancer treatment. The effectiveness of kinases as targets for other diseases, including neurological disorders, inflammation and metabolic diseases, is also being tested. Human protein kinase consists of more ...

Aug. 11, 2021

By BOC Sciences

Design and R&D of Covalent Drugs

For a long time, electrophilic groups have been a minefield in drug development. Therefore, in the classic medicinal chemistry textbooks of the past, it is always recommended to avoid introducing functional groups such as epoxide, acridine and Michael receptor into the structure of drug molecules, because these functional groups are highly reactive and may interact with a wide range of biological ...

Aug. 8, 2021

By BOC Sciences

Developing Research and Medical Diagnostic Products

The demand for research and MEDICAL DIAGNOSTIC products grows annually. Because medical diagnostic devices are used in the testing, treatment, prevention, monitoring, studying, and diagnosis of diseases and other biological human conditions, companies that develop and manufacture such diagnostic products are well positioned to serve an important and vital role in health and healthcare, the ...

Aug. 4, 2021

By BMP Medical

What are the ADC drugs?

Antibody-drug conjugates (ADCs) continue to rise at home and abroad, but ADCs are not a new thing. Why has ADC been surging for so many years? What kind of magic power it contains, and what makes its growth path so tortuous? Let's take a brief look at the magical "magic bullet"-ADC. ADC (antibody-conjugated drug) is not a new concept. As early as the early 20th century, the Nobel Prize winner ...

Aug. 2, 2021

By BOC Sciences

Exploring Knowledge Graphs for COVID-19 Drug Discovery

Today, there are only a few therapies approved to treat COVID-19, but while novel therapies can take decades and billions of dollars to develop, are there opportunities to repurpose existing drugs for new therapies? Our latest whitepaper showcases how CAS Knowledge Graphs reveal new connections and insights that identify drugs to potentially repurpose. Drug repurposing is critical for faster ...

Jul. 29, 2021

By Chemical Abstracts Service (CAS)

Temple research finds that tweaking CBD may help it curb pain and opioid use in mice

Doylestown-based Neuropathix is running safety tests required to start clinical trials in humans. The compound may help with neuropathy, a severe type of chronic pain associated with cancer treatment. The next generation of cannabis-inspired medicine might be grown in test tubes instead of greenhouses. Researchers at Temple University have partnered with Doylestown-based pharmaceutical company ...

Jul. 6, 2021

By Neuropathix, Inc.

Anti Helicobacter Pylori Formula Shows Initial Results

Helicobacter pylori (Hp) is closely related to the occurrence and development of gastric cancer, peptic ulcer, Hp-related dyspepsia and other diseases. Studies have found that Hp can cause gastric microbial disorders, change the microbial diversity and community structure in the stomach, and cause precancerous lesions. The public health community has made great efforts to eradicate Hp for a long ...

Jun. 14, 2021

By Creative Enzymes

First-in-man demonstration of 18-month spatiotemporal stability of active atrial fibrillation source detected by Electrographic Flow mapping in persistent atrial fibrillation

Keywords: atrial fibrillation, catheter ablation, mapping, atrial fibrillation, source, electrographic flow Introduction: Advanced mapping methods for atrial fibrillation (AF) have previously suffered from poor spatiotemporal stability. Electrographic flow (EGF) mapping is a novel technique using computer vision and optical flow smoothing algorithms to avoid this issue. The aim of this ...

Jun. 13, 2021

By Ablacon, Inc.

Getting Together: How GE`s Health Innovation Village Used Tech to Help Seniors During the Pandemic

The COVID-19 pandemic forced companies the world over to adapt. For a diverse group of Finnish technology businesses, it also opened doors to a market that tech entrepreneurs sometimes ignore: seniors. Brought together by their membership in GE’s Health Innovation Village in Helsinki, the leaders of these small but growing firms noticed a paradox. COVID-19 left the elderly more isolated ...

Jun. 8, 2021

By GE Renewable Energy

Landmark study confirms that controlled blood pressure is key to prevent stroke, heart disease

Follow-up data from the landmark SPRINT study of the effect of high blood pressure on cardiovascular disease have confirmed that aggressive blood pressure management — lowering systolic blood pressure to less than 120 mm Hg — dramatically reduces the risk of heart disease, stroke, and death from these diseases, as well as death from all causes, compared to lowering ...

May 24, 2021

By Cardiox Corporation

How Medical Studies are Changing the World

The coronavirus pandemic remains one of the top concerns within the United States. However, Johns Hopkins, and other research centers, are actively working to continue medical research in all divisions of medicine and health. Learn the ongoing studies at Johns Hopkins, what issues they are solving and how we can all make a difference. ...

May 11, 2021

By C&A Scientific

Latest data on the safety and effectiveness of COVID-19 vaccines in children

Childhood vaccinations provide immunity to children against serious infectious diseases before they are exposed to them to prevent illness. Many childhood diseases, such as smallpox and polio, have been almost completely eradicated as a result of widespread, standardized childhood vaccination programs. Some vaccinations, such as those for highly contagious diseases including measles, mumps, ...

May 10, 2021

By Chemical Abstracts Service (CAS)

Plasma medicine: Using cold atmospheric pressures in dermatology

The research of atmospheric plasma’s use for medical treatments has gathered apace over recent years. Plasma comprises charged particles as well as a range of other active components that are thought to interact with the body to produce desired affects in plasma medicine such as; electric current, UV radiation and reactive gas species these components are thought to be able to act ...

Apr. 30, 2021

By Hiden Analytical Ltd.