Pre-Clinical Articles
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Signs of Parkinson’s Disease to Watch For
Parkinson’s disease is a progressive neurodegenerative disease that is most commonly known for affecting movement. It primarily impacts dopaminergic, or dopamine-producing, neurons in a specific area of the brain known as the substantia nigra. Typically, symptoms develop slowly over years and continue to worsen as the disease progresses. While the manifestation of symptoms tends to vary ...
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How the Ubibot Device and Platform Could Guarantee Vaccine’s Storage During Its Develop and Transportation
Just as with any medical equipment out there or any vaccine, doctors, researchers, and transportation experts must know some things.Development From the very moment that they are developed, vaccines and the equipment there need to be monitored at all times, or in other words, the room needs to remain at a specific level of both temperature and humidity.This can be done through the following ...
By UbiBot
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Breakdown of How Sugar Impacts The Brain and Cognitive Function
It is no secret that glucose, a form of sugar, is the main source of energy for every cell in our bodies, including our brain cells. Because the brain is packed with neurons, it uses more energy than any other organ in the body. Our brains reward us for consuming sugar. Whether you are eating a delicious meal, sharing a kiss with someone you love, or enjoying a sugary treat, the mesolimbic ...
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Project - A novel host-protein Point-Of-Care platform for differentiating bacterial vs viral infections: Transition from prototype to product
Project name: A novel host-protein Point-Of-Care platform for differentiating bacterial vs viral infections: Transition from prototype to product Funding: $4,079,159 Aim: To support transfer to manufacturing of MeMed's pioneering point of care platform (MeMed Key™) that distinguishes bacterial from viral infections The two-year grant from the DOD's Congressionally Directed Medical ...
By MeMed
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How to Measure Cognitive Decline In Older Patients
Primary care practitioners are often the first to address a patient’s or family’s concerns about memory loss or the possibility of dementia. Detecting cognitive decline as early as possible is fundamental to a patient’s ability to receive earlier access to treatments and therapies, and, consequently, more effective treatment and improved health outcomes. There are several ...
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The Endocannabinoid System, A Physician`s Perspective
Most physicians are constantly learning not only for their benefit but, more importantly, for the benefit of their patients. It is not surprising therefore that there is considerable interest in the endocannabinoid system (ECS) as this system has only been recently recognized and appreciated. I think it is fair to say that over the last decade there has been more interest in the ECS than any ...
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In the NFL `Afterlife` everything hurts
Not too long ago in the August 4th version of the San Jose Mercury News, reporter Elliott Almond caught up with NFL Hall-of-Fame quarterback Jim Plunkett to talk about life after football. His response made headlines. "My life sucks", said Plunkett, now 69. "It’s no fun being in this body right now. Everything hurts." The years of daily pain pulsating from the neck, back, knees, ...
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Pain and the Endocannabinoid System, A Physicians Perspective
The topic of pain and pain control is a very complex one with many different areas of concern and consideration. I will try to outline this complex topic as it applies to the endocannabinoid system. In my last article I briefly outlined this system and described it as an internal “buffer” the main function of which is to create homeostasis within our body. When considering the ...
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Mutation-directed Neo-protein-protein Interactions in Cancer
Genetic mutations in cells are an important cause of cancer development, progression, and drug resistance. How to quickly and accurately translate massive tumor genomic information into safe and effective cancer targeted therapies in clinical practice is a scientific frontier today. At present, a large number of scientific studies have focused on how oncogenic mutations regulate the activity of ...
By Profacgen
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Targeting Interleukin-6 Helps to Mitigate the Side Effects of Immunotherapy
Researchers at The University of Texas MD Anderson Cancer Center have identified a new strategy to reduce immune-related adverse events by targeting immunotherapy with the cytokine interleukin-6 (IL-6). The study, published in Cancer Cell, provides evidence for the concept of combining immune checkpoint blockers and cytokine blockers to selectively inhibit inflammatory autoimmune responses. ...
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Silk Fibroin Enhances Tendon Repair and Tissue Regeneration
Researchers at the Terasaki Institute for Biomedical Innovation have used silk protein, which is produced by silkworms, as a biomaterial for tendon repair. The researchers report that their approach has made significant progress in tendon regeneration of mesenchymal stem cells (MSCs). SF is a promising biomaterial for tendon repair, but its relatively rigid mechanical properties and low cell ...
By Matexcel
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Titanium but not just titanium
Titanium and its alloys have many advantages as surgical implant materials, such as low density, high strength, good toughness, good biocompatibility, non-toxicity, low elastic modulus, good corrosion resistance, and low X-ray absorption rate Etc., thus occupying an increasingly important position in medical metal materials. Titanium and its alloys can be used for the repair and replacement of ...
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A Novel Potential Target for CAR-T Cell Therapy in Human Solid Tumors Discovered
At present, chimeric antigen receptor T cell therapy (CAR-T) has made significant achievements in the treatment of specific hematological cancers, allowing patients with relapsed/refractory disease to survive longer and become healthier, but in clinical studies, cell therapy has actually not been successful in the treatment of patients with solid tumors, in part due to the lack of tumor targets ...
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Near-atomic-level Details of Cancer Proteins with the Help of Molecular Cages Revealed
Sandwiching the wobble protein between two other layers allowed scientists to get the most detailed picture of a protein that is key to the spread of acute myeloid leukemia. Acute myeloid leukemia (AML) afflicts more than 20,000 Americans each year, killing more than 11,000 of them, according to the American Cancer Institute. And many people who receive intensive chemotherapy or stem cell ...
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LncRNA Sequencing Helps to Find Deep Links to Disease
Long non-coding RNAs (lncRNAs) are a class of RNAs that do not code for proteins and are typically greater than 200 nucleotides in length. Studies have shown that lncRNAs are quite complex in function and play an important role in various biological processes such as development, differentiation, proliferation, metastasis, apoptosis, stem cell pluripotency, and DNA damage. Therefore, those ...
By CD Genomics
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AI Designed Mutation Resistant Broad Neutralization Antibodies Against Multiple SARS-CoV-2 Strains based on A Digital Twin of COVID-19 - Case study
Introduction The emerging variants including Delta and Omicron may not retain activity with current available mAb products that were developed during the initial outbreak with the B.l strain. In this study, we have applied AI technologies in the computational design of broad neutralization antibodies against over 1300 different historical SARS-CoV-2 strains with very small computational cost. ...
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Bioinformatics Analysis Brings Disease Genomics Research to a Crossroads
Introduction Since the completion of the Human Genome Project, genomics has played an increasingly critical role in the biomedical field. Its applications include variation and risk assessment in disease genomics, analysis of changes in transcriptomic gene expression, revealing epigenetic effects on tissue and organ development, and heterogeneity at the single-cell level, among others. We present ...
By CD Genomics
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Using AI to Fight a Pandemic: Insilico Medicine Announces Novel Preclinical Candidate for COVID-19 Treatment
Insilico Medicine announced the nomination of a novel preclinical therapeutic candidate for treating COVID-19, designed using the generative chemistry AI platform Chemistry42. The new drug candidate is a 3CL protease inhibitor unique from existing drugs in its class because it can be rapidly produced. While this nomination is a potentially important development for the ongoing COVID-19 pandemic ...
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Huateng Pharma Supplies Canagliflozin Intermediates With Commercial Scale Production
Canagliflozin is a medication used to treat type 2 diabetes. It is a third-line medication to be tried after metformin, a first-line medication for type 2 diabetes. It is used together with exercise and diet. It is not recommended in type 1 diabetes. Mechanism action of Canagliflozin Canagliflozin is a sodium-glucose cotransporter (SGLT2) inhibitor. Glucose filtered in the renal tubular lumen is ...
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The Link Between Smoking and Cognitive Decline
By now, you are likely aware of many of the well-established risks associated with smoking cigarettes, such as cancer, asthma, chronic obstructive pulmonary disease (COPD), diabetes, cardiovascular disease, and stroke. But did you know that research has discovered a link between smoking and cognitive decline? This research emphasizes the importance of identifying and controlling modifiable risk ...
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