Drug Discovery - Pre-Clinical Information

Articles & Whitepapers

Developing a Robust in Vitro Intestinal Model for Preclinical Candidate Screening of GI Toxicity

Gastrointestinal (GI) issues are common side effects of many drugs. Anticipating such side effects before clinical trials is limited by a lack of effective models for evaluating preclinical candidates for their potential to cause diarrhea, nausea, and other gut-related side effects. With its RepliGut® in vitro human intestinal model, Altis Biosystems is developing a system that could help ...

Comparing Voxel-Based and Graph-Based Convolutional Neural Network Models to Quantitatively Predict Binding Affinity Globally Across Structures and Ligands

Abstract After identifying and validating initial hits, drug discovery progresses through hit-to-lead and lead-optimization stages. Quantitatively predicting binding affinity accurately could ...

Creative Enzymes Upgrades Multiple Diagnostic Enzyme Products for Clinical and Diagnostic Research

Creative Enzymes, the world’s leading diagnostic enzyme production company, has been committed to providing customers with various enzyme products and services for medical and research diagnosis. Relying on its professional team and the most ...

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G Protein-Coupled Receptors (GPCRs) Technology

G protein-coupled receptors (GPCRs) are the largest and most diverse group of membrane receptors in the body. They play a key role in a broad range of biological processes by binding to a wide variety of signaling molecules, yet they share a common architecture. GPCRs are comprised of seven transmembrane (TM) helices that span the cell membrane and intervening loops that are presented towards ...