Preclinical Drug Applications
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dasabuvir
Dasabuvir is an antiviral drug for the treatment of hepatitis C. It inhibits hepatitis C virus (HCV) non-nucleoside NS5B palm polymerase to suppress RNA replicase. https://www.bocsci.com/dasabuvir-cas-1132935-63-7-item-462255.html ...
By Alfa Chemistry based in NY, NEW YORK (USA).
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Human biology solutions for ADME-Tox sector
Increase clinical translation with Organ-Chips for ADME-Tox assessments. Accurate ADME-Tox profiling of preclinical drug candidates remains a challenge. Preclinical ADME-Tox (Absorption, Distribution, Metabolism, Excretion, and Toxicity) studies are pivotal to predicting human response. However, approximately 30% of drugs fail during human clinical trials due to adverse reactions despite promising preclinical study results, and another 60% fail due to lack of efficacy. As companies broaden the modality toolbox ...
By Emulate based in Boston, MASSACHUSETTS (USA).
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Highly customized aptamer discovery solutions for aptamers in neurological disease sector
More than 5 million people in the United States and an estimated 50 million people worldwide are living with Alzheimer’s disease. More than 10 million people worldwide are living with Parkinson’s. Brain tumors and tumors of the central nervous system are the most common form of cancer in children under 19 and the leading cause of cancer-related deaths in children under 14 in the U.S. While antibody drugs have made great strides in cancer therapies, crossing the blood-brain barrier (BBB) and ...
By Base Pair Biotechnologies, Inc. based in Pearland, TEXAS (USA).
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Highly customized aptamer discovery solutions for hot areas for aptamers sector
Aptamers are short strands of DNA or RNA with unique secondary and tertiary structures that enable highly selective binding to various types of targets. While aptamers are similar to antibodies in their ability to specifically bind with high affinity, there are some key differences between antibodies and aptamers which have prompted an increase in aptamer development projects. Several hot areas for aptamers, along with specific aptamer advantages, are outlined below. ...
By Base Pair Biotechnologies, Inc. based in Pearland, TEXAS (USA).
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Highly customized aptamer discovery solutions for therapeutic aptamers sector
As targeted therapies evolve and the limitations of antibody-based therapies become clearer, a growing number of research teams are exploring the therapeutic potential of ...
By Base Pair Biotechnologies, Inc. based in Pearland, TEXAS (USA).
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Highly customized aptamer discovery solutions for drug delivery sector
In many therapeutic areas, current treatments involve significant side effects. Combining drug compounds with affinity agents that target specific cell surface receptors can dramatically reduce off-target effects and improve treatment effectiveness. In several studies, aptamer-mediated drug delivery has reduced toxicity and improved drug performance. ...
By Base Pair Biotechnologies, Inc. based in Pearland, TEXAS (USA).
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FluidFM for Virology Study viral entry and replication on a single virion-single cell level
FluidFM® for Virology - Get a unique control over your single virion-single cell in-vitro experiment! Typically, viral infections are studied in bulk experiments where many cells in culture are exposed to the virus simultaneously, making it difficult to study single virus entry events or the spread of the viral infection between individual cells. With the gentle, micro-channeled, and force feedback-controlled FluidFM Probes, single virions can be deposited onto selected cells allowing unprecedented control to ...
By Cytosurge AG based in Glattbrugg, SWITZERLAND.
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Safety & efficacy testing solutions for small molecule drugs areas
Skimune® can predict first-in-man hypersensitivity or adverse immune reactions to small molecule ...
By Alcyomics Ltd. based in Newcastle Upon Tyne, UNITED KINGDOM.
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