G Protein-Coupled Receptor (Preclinical Drug) Equipment
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based in SWITZERLAND
G Protein-Coupled Receptors (GPCRs) are involved in a wide range of physiological and pathological processes and represent a large class of drug targets accounting for >30% of all drugs on the market. These drugs, however, only cover 15% of the entire GPCR family, and many valuable receptors remain undrugged. ...
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Manufactured by Confo Therapeuticsbased in BELGIUM
G protein-coupled receptors (GPCRs) are the largest and most diverse group of membrane receptors in the body. They play a key role in a broad range of biological processes by binding to a wide variety of signaling molecules, yet they share a common architecture. GPCRs are comprised of seven transmembrane (TM) ...
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Manufactured by Mol Scientificbased in CHINA
Mol Scientific offer high-quality RFamide ligand for orphan G-protein-coupled receptor SP9155, P517 peptide product(MPE0005929). Mol Scientific committed to bring our esteemed customers high quality products and the finest services at highly competitive prices. ...
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Manufactured by Mol Scientificbased in CHINA
Mol Scientific offer high-quality RFamide ligand for orphan G-protein-coupled receptor SP9155, P52 peptide product(MPE0008281). Mol Scientific committed to bring our esteemed customers high quality products and the finest services at highly competitive prices. ...
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Manufactured by Systasy Bioscience GmbHbased in GERMANY
Barcoded profiling of G protein coupled receptor (GPCR) and receptor tyrosine kinase (RTK) activities, resolving multi-specific drug ...
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Manufactured by Systasy Bioscience GmbHbased in GERMANY
and in the cytosol of the cell. This feature makes it, for example, an invaluable tool to assess the activity of receptors as measured by the regulated binding to their cognate cytosolic adapters. Therefore, this technology can be applied in particular to assess compound actions on drug targets, such as G protein-coupled ...
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Manufactured by BCN Peptides S.A.based in SPAIN
Abaloparatide is 34 amino acid synthetic analog of parathyroid hormone-related protein (PTHrP) (1-34). It works as an anabolic agent for the bone, through selective activation of the parathyroid hormone 1 receptor (PTH1R), a G protein-coupled receptor (GPCR) expressed in the osteoblasts and ...
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Manufactured by Creative Peptidesbased in USA
and shown to be a member of the seven-transmembrane, G protein-coupled receptor family.http://www.creative-peptides.com/product/calcitonin-salmon-item-10-101-08-23.html ...
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Manufactured by Kymab, a Sanofi companybased in UNITED KINGDOM
Accessing a new repertoire of targets. Two classes of molecule with therapeutic potential that are not currently addressed by antibody drugs are G-protein-coupled receptors and ion channels, largely because they display small epitopes not accessible to traditional antibodies and their sequence is often conserved and thus less ...
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Manufactured by Protein Foundry LLC.based in USA
Human CXCL2 is a 73 amino acid, ELR+ chemokine that belongs to the GRO isoform subset which activates the G protein-coupled receptors CXCR2. LPS-stimulated macrophages strongly express CXCL2 in addition to the constitutive expression by macrophages. CXCL1 is a potent chemoattractant for neutrophils and hematopoietic stem cells ...
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Manufactured by Protein Foundry LLC.based in USA
Human CXCL4, additionally known as Platelet-factor 4, is a 70 amino acid protein that is released by activated platelets to promote coagulation. CXCL4 binds to the G protein-coupled receptor CXCR3-B, found in kidney, heart and liver tissue, but a canonical signaling receptor is still unknown. ...
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Manufactured by Protein Foundry LLC.based in USA
Human CCL5, also known as Regulated upon Activation, Normal T cell Expressed and presumably Secreted (RANTES), attracts and activates leukocytes and plays a primary role in the inflammatory immune response. CCL5 activates several G protein-coupled receptors including CCRs 1, 3, 4, and 5. CCL5 binding to CCR5 inhibits the ...
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Manufactured by OSE Immunotherapeuticsbased in FRANCE
OSE-230 is an agonist antibody against ChemR23, also known as chemerin chemokine-like receptor 1 (CMKLR1), a G-protein coupled receptor (GPCR) expressed on myeloid immune cells known to modulate inflammation. Persistent inflammation is a characteristic feature of all chronic inflammatory or autoimmune diseases ...
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Manufactured by Echelon Biosciences, Inc (EBI)based in USA
, and smooth muscle contraction. LPA binds to several G-coupled protein receptors to initiate its biological functions. In cancer, LPA primarily promotes cell survival, migration and ...
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Manufactured by Confo Therapeuticsbased in BELGIUM
Confo Therapeutics is building a pipeline of drug candidates with the potential to transform therapeutic outcomes for patients with severe illnesses lacking disease-modifying ...
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Manufactured by Addex Therapeuticsbased in SWITZERLAND
Allosteric modulators are an emerging class of orally available small molecule therapeutic agents that may offer a competitive advantage over classical ...
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Manufactured by ProSpec-Tany TechnoGene Ltd.based in ISRAEL
BCA 1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain topological domain containing 110 amino acids (23-109 a.a) and having a molecular mass of 12.7kDa. BCA 1 is fused to a 23 amino acid His-tag at N-terminus. SYNONYMS: C-X-C motif chemokine 13, Small-inducible cytokine B13, B lymphocyte chemoattractant, CXC chemokine BLC, CXCL13, BCA1, BCA-1, CXCL-13, B cell ...
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Manufactured by ProSpec-Tany TechnoGene Ltd.based in ISRAEL
BCA-1/ BLC (CXCL13) Rhesus Macaque Recombinant produced in E.Coli is a non-glycosylated polypeptide chain containing 87 amino acid and having a molecular mass of approximately 10.3kDa. SYNONYMS: C-X-C motif chemokine 13, Small-inducible cytokine B13, B lymphocyte chemoattractant, CXC chemokine BLC, CXCL13, BCA1, BCA-1, CXCL-13, B cell Attracting Chemokine-1, BLC, ANGIE, BLR1L, SCYB13, ...
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based in AUSTRALIA
An i-body is a human protein that belongs to the class of next generation antibodies. The i-body is built on the scaffold of a human protein and engineered with two loops that mimic the shape of shark antibodies. These loops are responsible for binding or interacting with a particular target (in circulation or on a cell) that is causing disease. ...
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Manufactured by SYnAbs S.A.based in BELGIUM
Transmembrane proteins are probably the most complex and challenging antigens to target with monoclonal antibodies. Indeed, despite their strong presence in the animal kingdom and their implications in many cellular mechanisms, they remain very difficult to access due to intrinsic properties. ...
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