Alfa Chemistry Pre-Clinical Services
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Manufactured by Alfa Chemistrybased in USA
Nitrocellulose (NC) membranes are a series of paper-like matrices with micro-scale porous structures. Due to their good biocompatibility, unique physical and chemical properties, and the ability to immobilize various biomolecules, NC membranes have been widely used in the biomedical field. For example, NC membranes are commonly used to immobilize nucleic acids in southern blots and northern ...
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Manufactured by Alfa Chemistrybased in USA
Dexmedetomidine hydrochloride is a white or almost white powder that is freely soluble in water and has a pKa of 7.1. Dexmedetomidine hydrochloride is a potent α2-adrenoceptor agonist, which produces and analgesia, about 8 times higher selective affinity for the α2/α1-adrenoceptor than clonidine. Alfa Chemistry offers high quality of dexmedetomidine hydrochloride which meets the CP & EP ...
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Manufactured by Alfa Chemistrybased in USA
Tamoxifen citrate is an estrogen receptor antagonist and partial agonist which has been shown to induce apoptosis in human malignant glioma cells and to block VEGF production in breast cancer cells. Alfa Chemistry offers high quality tamoxifen citrate to customers which meets the CP & USP standards. Please feel free to contact us for APIs or technical services. Learn more at ...
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Manufactured by Alfa Chemistrybased in USA
Catalysis and Reaction Mechanism Calculation: The reaction energy and reaction rate constant is analyzed through the atomic charge analysis of several important atoms participating in the reaction. In terms of complete reaction mechanism calculation, bond breaking, bond formation, transition state, and sometimes catalysis are necessarily taken into ...
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Manufactured by Alfa Chemistrybased in USA
Lot release testing includes physical and chemical testing to ensure that the product meets the defined specifications. It is not only a key component of the quality control process for biologics, but also the basis for drug development. Before a biological product can be released for use, sale or export, lot release testing must be performed. We have the ability to provide you with lot release ...
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Manufactured by Alfa Chemistrybased in USA
Donepezil is a white or almost white crystalline powder and is freely soluble in chloroform, soluble in water and in glacial acetic acid, slightly soluble in ethanol and in acetonitrile, and practically insoluble in ethyl acetate and in n-hexane. Donepezil is a potent, selective, noncompetitive, and rapidly reversible inhibitor of acetylcholinesterase (AChEI) licensed for the treatment of ...
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Manufactured by Alfa Chemistrybased in USA
Drug Discovery and Research: Alfa Chemistry aims to support efforts to generate novel drugs by serving as a one-stop platform for the variety of services and expertise needed for drug discovery and development. We will collaborate through a combination of integrated, multidisciplinary drug discovery expertise and capabilities across modality targets, platforms and therapeutic areas. We use a ...
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Manufactured by Alfa Chemistrybased in USA
As one of the best medicinal chemistry team in the world, Alfa Chemistry offer comprehensive medicinal chemistry support to biotech and pharmaceutical companies engaged in drug discovery and research. We can provide service for all stages of medicinal chemistry activities including hit generation and target validation, hit-to-lead optimization, lead optimization and preclinical development. We ...
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Manufactured by Alfa Chemistrybased in USA
Nowadays, computational methods are routinely used to accelerate drug discovery process. In drug design and discovery, multiple computational chemistry approaches are employed to calculate and predict events, such as the drug binding to its target and the chemical properties for designing potential new drugs. At Alfa Chemistry, we apply the knowledge of computational chemistry to create various ...
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Manufactured by Alfa Chemistrybased in USA
Contract Manufacturing Organization Alfa Chemistry is the one of the leading companies for ADC drug development in the world that provides technically challenging service from development to commercial production including both payload and ADC. Alfa CDMO is equipped with state-of-the-art fill/finish equipment with aseptic filling and lyophilization with automated operation to ensure manufacturing ...
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Manufactured by Alfa Chemistrybased in USA
The Alfa Chemistry platform integrates predictive methods with various computational techniques to accelerate drug discovery. Our iterative process is designed to accelerate evaluation and optimization of chemical matter in silico ahead of synthesis and assay. The most promising compounds emerging from each round of experimental project chemistry are then further optimized through additional ...
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Manufactured by Alfa Chemistrybased in USA
Calculation of Thermodynamic Data for Individual Chemical Reactions: Thermodynamic data for chemical reactions deals with the energy change in accordance with the laws of thermodynamics. This represents macroscopic properties of the system, that is the initial and final states not involving the mechanism. It is of great benefit to understand thermodynamic properties of chemical reactions for the ...
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Manufactured by Alfa Chemistrybased in USA
Vibration Circular Dichroism (VCD) Spectrum Prediction: As a new method for measuring the circular dichroism of molecules in the infrared wavelength region, VCD has greatly expanded the application range of circular dichroism. Scientists use it to accurately predict chirality through conformational search and quantum chemical calculations, and the chromatogram of the vibrational circular ...
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Manufactured by Alfa Chemistrybased in USA
Identification of Rate-limiting Reaction Steps: By analyzing the structure of the reaction intermediates and transition states, the rate-limiting steps of the reaction can be determined combined with kinetic methods. Several remarkable computational methods have been developed to search for the transition states and analyze the mechanism of the entire reaction. Scientists can therefore model the ...
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Manufactured by Alfa Chemistrybased in USA
Lead optimization is a complex and iterative process for identifying an improved drug lead with the goal of progressing to a preclinical candidate by altering the chemical structure of a confirmed hit. A diversity of properties such as target’s specificity, selectivity, pharmacodynamics, pharmacokinetics and toxicological properties are improved by modifying the chemical structures of compounds ...
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Manufactured by Alfa Chemistrybased in USA
Epalrestat is a carboxylic acid derivative and a noncompetitive and reversible aldose reductase inhibitor used for the treatment of diabetic neuropathy, which is one of the most common long-term complications in patients with diabetes mellitus. Alfa Chemistry offers high quality epalrestat to customers which meets the CP & JP standards. Please feel free to contact us for APIs or technical ...
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Manufactured by Alfa Chemistrybased in USA
Parecoxib sodium is a white or almost white crystalline powder with the chemical name sodium N-[4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)benzenesulfonyl]propanecarboximidate which is freely soluble in water, methanol, N,N-dimethylformamide. Parecoxib sodium is an amide prodrug of the cyclooxygenase II (COX-2) selective, non-steroidal anti-inflammatory drug (NSAID) valdecoxib, with anti-inflammatory, ...
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Manufactured by Alfa Chemistrybased in USA
Edaravone, a member of the substituted 2-pyrazolin-5-one class, has the chemical name 3-methyl-1-phenyl-2-pyrazolin-5-one. It is a white crystalline powder and is freely soluble in acetic acid, methanol, or ethanol, as well as slightly soluble in water or diethyl ether. Edaravone is available as a clear, colorless liquid provided as a sterile injection solution supplied for intravenous (IV) ...
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Manufactured by Alfa Chemistrybased in USA
Tofacitinib citrate, chemically named as (3R,4R)-3-[4-methyl-3-[N-methyl-N-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl]-3-oxopropionitrile citrate, is a white or almost white powder, which is lightly soluble in water, very slightly soluble in methanol, and practically insoluble in acetone. Tofacitinib citrate is a novel, oral Janus kinase (JAK) inhibitor for the treatment of rheumatoid ...
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Manufactured by Alfa Chemistrybased in USA
ORD Simulation Prediction: Optical rotation refers to when a beam of polarized light passes through a substance,the plane of polarized light rotates at a certain angle relative to its own direction of motion. The property of rotating polarized light that a substance has is called optical rotation. Materials with optical rotation include crystals, spin-polarized molecules and chiral molecules. For ...
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