MedChemExpress -Model Maprotiline hydrochloride -10347-81-6

FromMedChemExpress LLC (MCE)

Maprotiline hydrochloride is a highly selective noradrenergic reuptake inhibitor that has strong antidepressant, antitumor and neuropathic pain-relieving effects with oral activity. Maprotiline hydrochloride induces cancer cell apoptosis by targeting the ERK signaling pathway and CRABP1[1][2].

Maprotiline hydrochloride

MCE China：Maprotiline hydrochloride

Brand：MedChemExpress (MCE)

Cat. No.HY-B0444

CAS：10347-81-6

Purity：99.98%

Storage：4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Maprotiline hydrochloride is a highly selective noradrenergic reuptake inhibitor that has strong antidepressant, antitumor and neuropathic pain-relieving effects with oral activity. Maprotiline hydrochloride induces cancer cell apoptosis by targeting the ERK signaling pathway and CRABP1.

In Vitro：Maprotiline (0-20 μM, 0-72 h) hydrochloride inhibits the growth of Huh7 and HepG2 cells and induces cell apoptosis[1]. Maprotiline (0-20 μM, 0-72 h) hydrochloride inhibits the metastasis of liver cancer cells[1]. Maprotiline (0-20 μM, 72 h) hydrochloride affects the ERK pathway and inhibits the phosphorylation of SREBP2 in HepG2 and Huh7 cells[1]. Maprotiline hydrochloride targets CRABP1 and regulates cholesterol biosynthesis in HCC cells[1].

In Vivo：Maprotiline (20-40 mg/kg, intraperitoneal injection, twice a week for three weeks) hydrochloride inhibits liver cancer tumor growth in mice[1]. Maprotiline (3-30 mg/kg, intravenous injection, single dose) hydrochloride combined with the synthetic cannabinoid WIN 55,212-2 effectively reduces neuropathic pain in mice[2].

References：

[1]. Zheng C, et al. Maprotiline Suppresses Cholesterol Biosynthesis and Hepatocellular Carcinoma Progression Through Direct Targeting of CRABP1. Front Pharmacol. 2021 May 20. 12:689767. [Content Brief]

[2]. Gunduz O, et al. Analysis of the anti-allodynic effects of combination of a synthetic cannabinoid and a selective noradrenaline re-uptake inhibitor in nerve injury-induced neuropathic mice. Eur J Pain. 2016 Mar. 20(3):465-71.

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