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Citronellol

MCE China：Citronellol

Brand：MedChemExpress (MCE)

Cat. No.HY-W010201

CAS：106-22-9

Synonyms：(±)-Citronellol; (±)-β-Citronellol

Purity：98.60%

Storage：4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Citronellol ((±)-Citronellol) is an orally active inducer of apoptosis. Citronellol can prevent oxidative stress, mitochondrial dysfunction, and apoptosis in the SH-SY5Y cell Parkinson's disease model induced by 6-OHDA by regulating the ROS-NO, MAPK/ERK, and PI3K/Akt signaling pathways. Citronellol can induce necroptosis in human lung cancer cells through the TNF-α pathway and accumulation of ROS. Citronellol can reduce the levels of LC-3 and p62 to regulate the autophagy pathway, inhibit oxidative stress and neuroinflammation, and thus have neuroprotective effects on Parkinson's rats. Citronellol exhibits anti-fungal activity against Trichophyton rubrum by inhibiting ergosterol synthesis.

In Vitro：Citronellol (50, 100 μg/mL, 72 h) can prevent oxidative stress, mitochondrial dysfunction, and apoptosis in the SH-SY5Y cell Parkinson's disease model induced by 6-OHDA by regulating the ROS-NO, MAPK/ERK, and PI3K/Akt signaling pathways[2]. Citronellol can be used as a skin contact allergen after forming hydrogen peroxide through self oxidation[3]. Citronellol (0-100 μg/mL, 48 h) can induce necrotic apoptosis in human lung cancer cell line NCI-H1299 through the TNF-α pathway and accumulation of reactive oxygen species[6]. Citronellol (0-100 μg/mL, 48 h) exhibits cytotoxicity towards A549, NCI-H1299, NCI-H23, BT-20, and PC3 cells, with IC50 values of 54.02, 40.64, 52.51, 45.84, and 50.1 μg/mL, respectively[6].

In Vivo：Citronellol (25, 50, 100 mg/kg; once daily; 2 weeks; p.o.) has a cardioprotective effect on the cardiotoxicity of Doxorubicin (HY-15142A) induced myocardial ischemia in rats[1]. Citronellol (25 mg/kg; once daily; 4 weeks; p.o.) can reduce the levels of LC-3 and p62 to regulate autophagy pathway, inhibit oxidative stress and neuroinflammation, thereby exerting neuroprotective effects on Parkinson's rats[4]. Citronellol (50, 100 mg/kg; once daily; 4 days; p.o.) can protect the kidneys in rhabdomyolysis induced acute kidney injury in mice through its anti apoptotic effect[5]. Citronellol (12.5, 25, 50 mg/kg; once daily; 20 days; i.p.) exhibits anti-tumor activity in non-small cell lung cancer mice[6].

IC50 & Target：IC50: 54.02，40.64，52.51，45.84，50.1 μg/mL (A549、NCI-H1299、NCI-H23、BT-20、PC3 cells) (Apoptosis)[6]. Cellular Effect Cell Line Type Value Description References

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References：

[1]. Munir S, et al. The Protective Effect of Citronellol against Doxorubicin-Induced Cardiotoxicity in Rats. Biomedicines. 2023 Oct 18;11(10):2820.  [Content Brief]

[2]. Shao J, et al. Citronellol Prevents 6-OHDA-Induced Oxidative Stress, Mitochondrial Dysfunction, and Apoptosis in Parkinson Disease Model of SH-SY5Y Cells via Modulating ROS-NO, MAPK/ERK, and PI3K/Akt Signaling Pathways. Neurotox Res. 2022 Dec;40(6):2221-2237.  [Content Brief]

[3]. Sahli F, et al. Autoxidized citronellol: Free radicals as potential sparkles to ignite the fragrance induced skin sensitizing pathway. Food Chem Toxicol. 2022 Aug;166:113201.  [Content Brief]

[4]. Jayaraj RL, et al. Effect of citronellol on oxidative stress, neuroinflammation and autophagy pathways in an in vivo model of Parkinson's disease. Heliyon. 2022 Nov 3;8(11):e11434.  [Content Brief]

[5]. Mahmood YS, et al. Protective effect of citronellol in rhabdomyolysis-induced acute kidney injury in mice. J Med Life. 2023 Jul;16(7):1057-1061.  [Content Brief]

[6]. Yu WN, et al. Citronellol Induces Necroptosis of Human Lung Cancer Cells via TNF-α Pathway and Reactive Oxygen Species Accumulation. In Vivo. 2019 Jul-Aug;33(4):1193-1201.  [Content Brief]

[7]. Pereira Fde O, et al. Antifungal activity of geraniol and citronellol, two monoterpenes alcohols, against Trichophyton rubrum involves inhibition of ergosterol biosynthesis. Pharm Biol. 2015 Feb;53(2):228-34.  [Content Brief]