MedChemExpress - Model Lumiflavin - 1088-56-8

FromMedChemExpress LLC (MCE)

Lumiflavin (Lumiflavine), a riboflavine analog, causes significant inhibition of riboflavine uptake. Lumiflavin can effectively reduce the riboflavin enrichment in cancer stem-like cells (CSCs) and sensitize the effect of cisplatin Diamminedichloroplatinum (DDP) on CSCs. Lumiflavin is promising for research of ovarian cancer[1][2][3].

Lumiflavin

MCE China：Lumiflavin

Brand：MedChemExpress (MCE)

Cat. No.HY-121608

CAS：1088-56-8

Synonyms：Lumiflavine

Purity：99.79%

Storage：4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Lumiflavin (Lumiflavine), a riboflavine analog, causes significant inhibition of riboflavine uptake. Lumiflavin can effectively reduce the riboflavin enrichment in cancer stem-like cells (CSCs) and sensitize the effect of cisplatin Diamminedichloroplatinum (DDP) on CSCs. Lumiflavin is promising for research of ovarian cancer.

In Vitro：Lumiflavin (10-40 μM, 48 h) has synergistic effects with Diamminedichloroplatinum (DDP) (20 μM, 48 h) on CSCs in increasing mitochondrial function damage and apoptosis rates and decreasing clonic function[2]. Lumiflavin (0-80 μM, 72 h) reduces the formation of drug resistance and proportion of CSCs, increases CSCs/DDP apoptosis rate and reduces cell clone formation ability in ovarian cancer cell line OVCAR-3[3]. Lumiflavin (80 μM, 72 h) downregulates the protein expression of Notch signaling pathway in CSCs/DDP[3].

In Vivo：Lumiflavin (8 mg/kg, i.p., once a day for 25 days) has a synergistic cytotoxic effect on an ovarian cancer nude mice model by enhancing the DNA‐damage response and increasing the apoptotic protein expression[2]. Lumiflavin (4-16 mg/kg, s.c., once a day for 25 days) combined with DDP reduces tumor weight and inhibits tumor growth[3].

References：

[1]. H M Said, et al. Mechanism of riboflavine uptake by Caco-2 human intestinal epithelial cells. Am J Physiol. 1994 Jan;266(1 Pt 1):G15-21. [Content Brief]

[2]. Yang R, et al. Lumiflavin increases the sensitivity of ovarian cancer stem-like cells to cisplatin by interfering with riboflavin. J Cell Mol Med. 2019 Aug;23(8):5329-5339. [Content Brief]

[3]. Yang R, et al. Lumiflavin Reduces Cisplatin Resistance in Cancer Stem-Like Cells of OVCAR-3 Cell Line by Inducing Differentiation. Front Oncol. 2022 May 20;12:859275. [Content Brief]

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