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MedChemExpress - Model Monoolein - ...

MedChemExpress - Model Monoolein - 111-03-5

Monoolein is a biocompatible lipid molecule that can be used as a carrier for bone repair. Monoolein exhibits anti-inflammatory activity by inhibiting the immune response induced by LPS (HY-D1056). It exerts its anti-inflammatory effects by reducing the production of immune response factors such as IL-12 p40, IL-6, and TNF-α, and inhibiting the generation of NO. Monoolein can be used in drug delivery and research in the field of inflammatory diseases [1][2].

Monoolein

MCE China：Monoolein

Brand：MedChemExpress (MCE)

Cat. No.HY-128754

CAS：111-03-5

Purity：99.90%

Storage：Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Monoolein is a biocompatible lipid molecule that can be used as a carrier for bone repair. Monoolein exhibits anti-inflammatory activity by inhibiting the immune response induced by LPS (HY-D1056). It exerts its anti-inflammatory effects by reducing the production of immune response factors such as IL-12 p40, IL-6, and TNF-α, and inhibiting the generation of NO. Monoolein can be used in drug delivery and research in the field of inflammatory diseases .

In Vitro：Monoolein (1-10 μM, 1 hour) exerts anti-inflammatory effects in BMDCs and RAW264.7 cells by inhibiting LPS-induced immune responses, manifested as a reduction in IL-12 p40, IL-6, and TNF-α levels in BMDCs, and suppression of NO, IL-12 p40, IL-6, and TNF-α production in RAW264.7 cells [1].

In Vivo：Monoolein (carrying 5 μg rhBMP-2, applied to the bone defect area for 3 weeks and 6 weeks) can serve as a carrier for rhBMP-2, playing a role in bone repair and demonstrating good biocompatibility and protein release properties [2].

IC50 & Target：Human Endogenous Metabolite

References：

[1]. Ali I, et al. Monoolein, isolated from Ishige sinicola, inhibits lipopolysaccharide-induced inflammatory response by attenuating mitogen-activated protein kinase and NF-κB pathways. Food Sci Biotechnol. 2017 Apr 30;26(2):507-511. [Content Brief]

[2]. Issa JP, et al. Monoolein and chitosan gels as potential carriers of the rhBMP-2, using decortication surgical technique in Wistar rats as experimental model. Micron. 2008 Oct;39(7):952-9. [Content Brief]

Brand introduction:
•   MCE (MedChemExpress) has a global exclusive compound library of more than 200 kinds, and we are committed to providing the most comprehensive range of high-quality small molecule active compounds for scientific research customers around the world；
•   More than 50,000 highly selective inhibitors and agonists are involved in various popular signaling pathways and disease areas；
•   The products cover a variety of recombinant proteins, peptides, commonly used kits, more PROTAC, ADC and other characteristic products, widely used in new drug research and development, life science and other scientific research projects；
•   Provide virtual screening, ion channel screening, metabolomics analysis detection analysis, drug screening and other professional technical services；
•   It has a professional experimental center and strict quality control and verification system；
•   Provide LC/MS, NMR, HPLC, chiral analysis, elemental analysis and other quality inspection reports to ensure the high purity and high quality of products；
•   The biological activity of the products has been verified by the experiments of customers in various countries；
•   A variety of top journals such as Nature, Cell, Science and pharmaceutical patents have included the scientific research results of MCE customers；
•   Our professional team tracks the latest pharmaceutical and life science research and provides you with the latest active compounds in the world；
•   It has established long-term cooperation with the world's major pharmaceutical companies and well-known scientific research institutions。