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MedChemExpress - Model SN-38 ...

MedChemExpress - Model SN-38 glucuronide - 121080-63-5

SN-38 glucuronide is an inactive metabolite of the anticancer active molecule Irinotecan (HY-16562) and has toxic effects on the gastrointestinal tract. Irinotecan is a topoisomerase I inhibitor which can be used for researching colon and rectal cancer[1][2][3].

SN-38 glucuronide

MCE China：SN-38 glucuronide

Brand：MedChemExpress (MCE)

Cat. No.HY-126373

CAS：121080-63-5

Synonyms：SN-38G

Purity：99.88%

Storage：Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month

Shipping：Room temperature in continental US; may vary elsewhere.

Description：SN-38 glucuronide is an inactive metabolite of the anticancer active molecule Irinotecan (HY-16562) and has toxic effects on the gastrointestinal tract. Irinotecan is a topoisomerase I inhibitor which can be used for researching colon and rectal cancer.

In Vitro：SN38-G is the glucuronidated metabolite of SN38. Cells with the ability to metabolize SN38 to SN38-G are more resistant to extracellular SN38 than cells lacking this capability[4].

In Vivo：SN-38 glucuronide can serve as a substrate for gut microbial β-glucuronidase enzymes, which remove the glucuronic acid moiety to reactivate SN-38 (HY-13704), thereby leading to the reactivation of SN-38 in the intestine, increasing its toxic effects on the gut[3].

References：

[1]. Pellock SJ, et al. Three structurally and functionally distinct β-glucuronidases from the human gut microbe Bacteroides uniformis. J Biol Chem. 2018;293(48):18559-18573. [Content Brief]

[2]. Atasilp C, et al. Determination of irinotecan, SN-38 and SN-38 glucuronide using HPLC/MS/MS: Application in a clinical pharmacokinetic and personalized medicine in colorectal cancer patients. J Clin Lab Anal. 2018 Jan;32(1):e22217. [Content Brief]

[3]. Wallace BD, et al. Alleviating cancer drug toxicity by inhibiting a bacterial enzyme. Science. 2010 Nov 5;330(6005):831-5. [Content Brief]

[4]. Ohtsuka K, et al. Intracellular conversion of irinotecan to its active form, SN-38, by native carboxylesterase in human non-small cell lung cancer[J]. Lung Cancer, 2003, 41(2): 187-198.

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