MedChemExpress - Model Cuminaldehyde - 122-03-2

FromMedChemExpress LLC (MCE)

Cuminaldehyde is the main component of Cuminum cyminum and has multiple biological activities, including anti-inflammatory, anti-cancer, anti-diabetic, anti-injury, anti-neuropathy and antibacterial effects. Cuminaldehyde is an inhibitor of aldose reductase (IC50= 0.00085 mg/mL), α-glucosidase (IC50=0.5 mg/mL) and lipoxygenase (IC50=1370 μM). Cuminaldehyde has potential application value in the research of neurodegenerative diseases, cancer, diabetes and neuropathic pain diseases[1][2][3][4][5][6][7].

Cuminaldehyde

MCE China：Cuminaldehyde

Brand：MedChemExpress (MCE)

Cat. No.HY-Y0790

CAS：122-03-2

Synonyms：p-Isopropylbenzaldehyde

Purity：99.03%

Storage：4°C, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Cuminaldehyde is the main component of Cuminum cyminum and has multiple biological activities, including anti-inflammatory, anti-cancer, anti-diabetic, anti-injury, anti-neuropathy and antibacterial effects. Cuminaldehyde is an inhibitor of aldose reductase (IC50= 0.00085 mg/mL), α-glucosidase (IC50=0.5 mg/mL) and lipoxygenase (IC50=1370 μM). Cuminaldehyde has potential application value in the research of neurodegenerative diseases, cancer, diabetes and neuropathic pain diseases.

In Vitro：Cuminaldehyde (1 mM; 24-96 h) can effectively inhibit α-synuclein (α-SN) fibrillation. The presence of α-SN fibrillation inducer Spermidine (HY-B1776) enhances the inhibitory effect, which is even stronger than the inhibitory effect of Baicalein (HY-N0196)[1]. Cuminaldehyde (0-160 μM; 12-48 h) inhibits the proliferation of human colon COLO 205 cells and induces cell apoptosis[2]. Cuminaldehyde (0.5 and 1.5 μM; 5 d) inhibits the growth of Aspergillus flavus (IC50=0.25 μL/mL) and induces necrosis of Aspergillus flavus[5]. Cuminaldehyde (0-0.8 μL/mL; 5 d) inhibits the synthesis of aflatoxin (AFB1), a secondary metabolite of Aspergillus flavus[5].

In Vivo：Cuminaldehyde (5-20 mg/kg; intratumoral injection; once a day for 42 days) inhibits tumor growth in mice bearing human colorectal cancer COLO 205 xenografts[2]. Cuminaldehyde (50-200 mg/kg; i.g.; single dose injection 30 minutes before hot plate test) significantly reduces the latency of nociceptive response in rats in hot plate test[6]. Cuminaldehyde (12.5-50 mg/kg; i.p.; single dose injection 30 minutes before the test) significantly inhibits pain perception in mice with abdominal pain induced by Acetic acid (HY-Y0319) and formalin[6]. Cuminaldehyde (25-100 mg/kg; i.p.; once daily for 14 days) significantly alleviates allodynia and hyperalgesia in rats with chronic constriction injury (CCI) model[6].

References：

[1]. Morshedi D, et al. Cuminaldehyde as the Major Component of Cuminum cyminum, a Natural Aldehyde with Inhibitory Effect on Alpha-Synuclein Fibrillation and Cytotoxicity. J Food Sci. 2015 Oct;80(10):H2336-45. [Content Brief]

[2]. Tsai, et al. "Cuminaldehyde from Cinnamomum verum induces cell death through targeting topoisomerase 1 and 2 in human colorectal adenocarcinoma COLO 205 cells." Nutrients 8.6 (2016): 318. [Content Brief]

[3]. Tomy, et al. "Cuminaldehyde as a lipoxygenase inhibitor: in vitro and in silico validation." Applied biochemistry and biotechnology 174 (2014): 388-397. [Content Brief]

[4]. Wongkattiya, et al. "Antibacterial activity of cuminaldehyde on food-borne pathogens, the bioactive component of essential oil from Cuminum cyminum L. collected in Thailand." Journal of Complementary and Integrative Medicine 16.4 (2019). [Content Brief]

[5]. Dan Xu, et al. "Cuminaldehyde in cumin essential oils prevents the growth and aflatoxin B1 biosynthesis of Aspergillus flavus in peanuts." Food Control 125 (2021): 107985.

[6]. Koohsari, et al. "Antinociceptive and antineuropathic effects of cuminaldehyde, the major constituent of Cuminum cyminum seeds: Possible mechanisms of action." Journal of ethnopharmacology 255 (2020): 112786. [Content Brief]

[7]. Hoi-Seon Lee, et al. "Cuminaldehyde: aldose reductase and α-glucosidase inhibitor derived from Cuminum cyminum L. seeds." Journal of agricultural and food chemistry 53.7 (2005): 2446-2450. [Content Brief]

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