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MedChemExpress - Model Rebaudioside M - ...

MedChemExpress - Model Rebaudioside M - 1220616-44-3

Rebaudioside M, a glycoside of the ent-kaurene diterpenoid aglycone, is a non-calorie sweetener isolated from Stevia rebaudiana. Rebaudioside M has antidiabetics, antihypertension, anti-inflammatory, antioxidant, anticaries and anticancer benefits. Rebaudioside M is more than 350 times sweeter than sucrose. Rebaudioside M can be used in food and beverage [1][2][3][4][5][6].

Rebaudioside M

MCE China：Rebaudioside M

Brand：MedChemExpress (MCE)

Cat. No.HY-N6833

CAS：1220616-44-3

Purity：99.61%

Storage：-20°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Rebaudioside M, a glycoside of the ent-kaurene diterpenoid aglycone, is a non-calorie sweetener isolated from Stevia rebaudiana. Rebaudioside M has antidiabetics, antihypertension, anti-inflammatory, antioxidant, anticaries and anticancer benefits. Rebaudioside M is more than 350 times sweeter than sucrose. Rebaudioside M can be used in food and beverage .

In Vitro：Rebaudioside M demonstrates to protect β-cell activity and enhance insulin secretion via increasing calcium influx into β-cells[3]. Rebaudioside M inhibits the PI3K/Akt signaling pathway resulting in lower cell proliferation and enhanced apoptosis and downregulates the Wnt/catenin signaling pathway in colon cancer cells, which is linked to reduced cell migration and invasion[6].

In Vivo：Rebaudioside M lowers fasting blood glucose levels and enhanced glucose tolerance in diabetic rats[3]. Rebaudioside M decreases oxidative stress and the production of pro-inflammatory cytokines in diabetic rats, protecting against pancreatic beta-cell damage[4]. Rebaudioside M reduces blood pressure via the suppression of angiotensin-converting enzyme, increases endothelial function and causes vasodilation in hypertensive rats[5].

References：

[1]. Prakash I, et al. Development of Next Generation Stevia Sweetener: Rebaudioside M. Foods. 2014 Feb 27;3(1):162-175. [Content Brief]

[2]. Xiaoqiang W, et al. Fusion glycosyltransferase design for enhanced conversion of rebaudioside A into rebaudioside M in cascade. Molecular Catalysis. 2023 Aug, 547: 113317.

[3]. Jeppesen PB, et al. Stevioside acts directly on pancreatic beta cells to secrete insulin: actions independent of cyclic adenosine monophosphate and adenosine triphosphate-sensitive K+-channel activity. Metabolism. 2000 Feb;49(2):208-14. [Content Brief]

[4]. Jan S A, et al. The anti-diabetic activities of natural sweetener plant Stevia: an updated review[J]. SN Applied Sciences, 2021, 3: 1-6.

[5]. Chakraborty R, et al. Angiotensin-converting enzyme inhibitors from plants: A review of their diversity, modes of action, prospects, and concerns in the management of diabetes-centric complications[J]. Journal of Integrative Medicine, 2021, 19(6): 478-492. [Content Brief]

[6]. Iatridis N, et al. Anti-Cancer Properties of Stevia rebaudiana; More than a Sweetener. Molecules. 2022 Feb 17;27(4):1362. [Content Brief]

Brand introduction:
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