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MedChemExpress - Model Protopine - ...

MedChemExpress - Model Protopine - 130-86-9

Protopine (Corydinine), an isoquinoline alkaloid, is a specific reversible and competitive inhibitor of acetylcholinesterase. Protopine exhibits anti-inflammation, anti-microbial, anti-angiogenic and anti-tumour activity[1][2].

Protopine

MCE China：Protopine

Brand：MedChemExpress (MCE)

Cat. No.HY-N0793

CAS：130-86-9

Synonyms：Corydinine

Purity：99.64%

Storage：Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Protopine (Corydinine), an isoquinoline alkaloid, is a specific reversible and competitive inhibitor of acetylcholinesterase. Protopine exhibits anti-inflammation, anti-microbial, anti-angiogenic and anti-tumour activity.

In Vitro：Protopine (10-40 μM, 24 h-96 h) inhibits cell viability, migration, invasion and EMT process of liver carcinoma cells (HepG2, Huh7)[2]. Protopine (10-40 μM, 24 h) induces apoptosis by increasing the expression of caspase-3 and caspase-9 in HepG2 and Huh7 cells, and inhibits the PI3K/Akt signaling pathway[2]. Protopine (10-40 μM, 6 h) induces generation of ROS in HepG2 and Huh7 cells[2]. Protopine (0-10 μg/mL) inhibits the uptake of serotonin transporter (SERT) in S6 cells and noradrenaline (NE) uptake in N1 cells[3].

In Vivo：Protopine (0.1 and 1 mg/kg, i.p.) alleviates Scopolamine (HY-N0296) (1 mg/kg)-induced memory impairment in mice[1]. Protopine (5-20 mg/kg, i.v.) inhibits tumor growth and inhibits PI3K/Akt, and induces cleavage of caspase-3 in xenograft BALB/c mice (s.c. with HepG2 or Huh-7 cells)[2]. Protopine (5-20 mg/kg, i.p.) shows antidepressant-like effect in mice HTR and TST tests[3]. Protopine (1-4 mg/kg, i.p., once daily for 3 days) shows protective effect on the focal cerebral ischaemic induced injury in rats[4].

References：

[1]. Kim SR, et, al. Protopine from Corydalis ternata has anticholinesterase and antiamnesic activities. Planta Med. 1999 Apr;65(3):218-21. [Content Brief]

[2]. Nie C, et, al. Protopine triggers apoptosis via the intrinsic pathway and regulation of ROS/PI3K/Akt signalling pathway in liver carcinoma. Cancer Cell Int. 2021 Jul 27;21(1):396. [Content Brief]

[3]. Xu LF, et al. Protopine inhibits serotonin transporter and noradrenaline transporter and has the antidepressant-like effect in mice models. Neuropharmacology. 2006 Jun;50(8):934-40. [Content Brief]

[4]. Xiao X, et al. Protective effect of protopine on the focal cerebral ischaemic injury in rats. Basic Clin Pharmacol Toxicol. 2007 Aug;101(2):85-9. [Content Brief]

Brand introduction:
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