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MedChemExpress - Model Oxythiamine - ...

MedChemExpress - Model Oxythiamine - 136-16-3

Oxythiamine (Hydroxythiamin), an analogue of anti-metabolite, can suppress the non-oxidative synthesis of ribose and induce cell apoptosis. Oxythiamine is a thiamine antagonist and inhibits transketolase (TK). Oxythiamine inhibits cancer cell apoptosis and inhibits cell proliferation[1][2][3].

Oxythiamine

MCE China：Oxythiamine

Brand：MedChemExpress (MCE)

Cat. No.HY-107430

CAS：136-16-3

Synonyms：Hydroxythiamin

Purity：96.36%

Storage：-20°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Oxythiamine (Hydroxythiamin), an analogue of anti-metabolite, can suppress the non-oxidative synthesis of ribose and induce cell apoptosis. Oxythiamine is a thiamine antagonist and inhibits transketolase (TK). Oxythiamine inhibits cancer cell apoptosis and inhibits cell proliferation.

In Vitro：Oxythiamine (0-40 μM, 2 days) inhibits cell viability of MIA PaCa-2 cells (IC50: 14.95 μM)[1]. Oxythiamine chloride hydrochloride (0-500 μM, 48 h) suppresses expression of 14-3-3 protein beta/alpha in MIA PaCa-2 cells[1]. Oxythiamine (0.1-100 μM, 6-48 h) inhibits A549 cell proliferation[3]. Oxythiamine (0.1-100 μM, 24 h) induces A549 cell apoptosis[3]. Oxythiamine (0-20 μM) inhibits the invasion and migration (IC50: 8.75 μM) of Lewis lung carcinoma (LLC) cells[4].

In Vivo：Oxythiamine (100-500 mg/kg, i.p. 4 days) inhibits tumor growth in Ehrlich's ascites tumor hosting mice[2]. Oxythiamine (250 or 500 mg/kg, daily for 5 week) inhibits tumor cell metastasis via inhibition of MMPs in mice implanted (s.c.) with LLC cells[4].

IC50 & Target：Vitamin B1, Thiamine, Transketolase[1]. In Vitro Oxythiamine (0-40 μM, 2 days) inhibits cell viability of MIA PaCa-2 cells (IC50: 14.95 μM)[1]. Oxythiamine chloride hydrochloride (0-500 μM, 48 h) suppresses expression of 14-3-3 protein beta/alpha in MIA PaCa-2 cells[1]. Oxythiamine (0.1-100 μM, 6-48 h) inhibits A549 cell proliferation[3]. Oxythiamine (0.1-100 μM, 24 h) induces A549 cell apoptosis[3]. Oxythiamine (0-20 μM) inhibits the invasion and migration (IC50: 8.75 μM) of Lewis lung carcinoma (LLC) cells[4]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Oxythiamine Related Antibodies Cell Viability Assay[1] Cell Line: MIA PaCa-2 cells

References：

[1]. Wang J, et al. Inhibition of transketolase by oxythiamine altered dynamics of protein signals in pancreatic cancer cells. Exp Hematol Oncol. 2013 Jul 27;2:18. [Content Brief]

[2]. Raïs B, et al. Oxythiamine and dehydroepiandrosterone induce a G1 phase cycle arrest in Ehrlich's tumor cells through inhibition of the pentose cycle. FEBS Lett. 1999 Jul 30;456(1):113-8. [Content Brief]

[3]. Bai L, et al. A dose- and time-dependent effect of oxythiamine on cell growth inhibition in non-small cell lung cancer. Cogn Neurodyn. 2022 Jun;16(3):633-641. [Content Brief]

[4]. Yang CM, et al. The in vitro and in vivo anti-metastatic efficacy of oxythiamine and the possible mechanisms of action. Clin Exp Metastasis. 2010 May;27(5):341-9. [Content Brief]

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