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Sodium tetradecyl sulfate

MCE China：Sodium tetradecyl sulfate

Brand：MedChemExpress (MCE)

Cat. No.HY-A0199

CAS：139-88-8

Synonyms：Tergitol 4

Storage：4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Sodium tetradecyl sulfate (Tergitol 4) is a novel scleroembolic agent and an apoptosis inducer. Sodium tetradecyl sulfate can be used for research on varicose veins and vascular malformation diseases.

In Vitro：Sodium tetradecyl sulfate induces endothelial activation and release of endothelial particles in human umbilical vein endothelial cells (HUVEC)[1]. Sodium tetradecyl sulfate can increase the expression of activation markers CD54 and CD62e in human umbilical vein endothelial cells (HUVEC), promoting HUVEC cell activation[1]. Sodium tetradecyl sulfate inhibits proliferation and induces apoptosis in mouse endothelial tumor (EOMA) cells[1].

In Vivo：Sodium tetradecyl sulfate (5 mL CH–STS; Intratumoral injection) can reduce type I leakage in bilateral iliac aneurysm models after forming gel (CH-STS) with chitosan[2]. Sodium tetradecyl sulfate (0.3 mL 1% STS; 30 days; i.v.) induces muscle inflammatory response in rats and has a vein blocking effect in the femoral vein[3]. Sodium tetradecyl sulfate (0.5 mL 1% STS; s.c.) can cause exudative skin necrosis in rats[4]. Sodium tetradecyl sulfate (0.2 mL of liquid STS 1% or 0.2 mL STS 1% sclerosing foam; i.v.) promotes the release of endothelin in rats and may lead to vascular spasm and cause neurological disorders[5].

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References：

[1]. Connor DE, et al. Sirolimus and propranolol inhibit endothelial proliferation while detergent sclerosants induce endothelial activation, microparticle release and apoptosis in vitro. Phlebology. 2020 Sep;35(8):566-575.  [Content Brief]

[2]. Zehtabi F, et al. Chitosan-Sodium Tetradecyl Sulfate Hydrogel: Characterization and Preclinical Evaluation of a Novel Sclerosing Embolizing Agent for the Treatment of Endoleaks. Cardiovasc Intervent Radiol. 2017 Apr;40(4):576-584.  [Content Brief]

[3]. Morsiani E, et al. Effect of intravenous and intraperivenous injections of sclerosants (sodium tetradecyl sulfate and hydroxy polyethoxy dodecan) on the rat femoral vein. Res Exp Med (Berl). 1987;187(6):439-49.  [Content Brief]

[4]. Zimmet SE. The prevention of cutaneous necrosis following extravasation of hypertonic saline and sodium tetradecyl sulfate. J Dermatol Surg Oncol. 1993 Jul;19(7):641-6.  [Content Brief]

[5]. Frullini A, et al. Significant endothelin release in patients treated with foam sclerotherapy. Dermatol Surg. 2012 May;38(5):741-7.  [Content Brief]