MCE products for research use only. We do not sell to patients.

Royal Jelly acid

MCE China：Royal Jelly acid

Brand：MedChemExpress (MCE)

Cat. No.HY-N1363

CAS：14113-05-4

Synonyms：(E)-Queen Bee Acid; (E)-10-Hydroxy-2-decenoic acid

Purity：99.42%

Storage：Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Royal Jelly Acid ((E)-Queen Bee Acid) is a major fatty acid found in royal jelly with oral bioavailability, exhibiting anti-inflammatory, anticancer, antimalarial, antiprotozoal, and neuroregulatory activities. Royal Jelly Acid can be used for research in various fields, including cancer, infections, immune inflammation, and neurological diseases.

In Vitro：Royal Jelly Acid (1-4 mM, 24 h) reduces NO production in RAW264.7 cells[3]. Royal Jelly Acid (1-4 mM, 24 h) inhibits IFN-β-induced NF-κB p65 phosphorylation in RAW264.7 cells, suggesting its regulatory role in inflammatory signaling pathways[3]. Royal Jelly Acid (10-100 µM, 24 h) reduces neurotrophic factor expression in Wistar rat cortical astrocytes[4]. Royal Jelly Acid (12.5-100 µg/mL, 72 h) exhibits strong antiplasmodial activity in Plasmodium falciparum K1 strain[5]. Royal Jelly Acid (1-8 µg/mL, 48 h) exhibits antileishmanial activity in Leishmania major amastigotes​[5]. Royal Jelly Acid (1.25-250 µg/mL, 24 h) induces cytotoxicity in MCF-7 breast cancer cells​[7]

In Vivo：Royal Jelly Acid (3–6 mg/kg, p.o., once daily for 25 days) significantly inhibits disease progression, reduces inflammatory cell infiltration, and prevents demyelination in the MOG35–55-induced experimental autoimmune encephalomyelitis C57BL/6 mouse model​[6].

Hot selling product：Sotagliflozin  | Aflatoxin M1  | Bupivacaine  | Hoechst 34580 (tetrahydrochloride)  | Oxibendazole  | Amodiaquine (dihydrochloride)  | Salicin  | Olmesartan  | Laminin 521, Human  | Chebulic acid

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides

References：

[1]. Weiser MJ, et al. Long-Term Administration of Queen Bee Acid (QBA) to Rodents Reduces Anxiety-Like Behavior, Promotes Neuronal Health and Improves Body Composition. Nutrients. 2017 Dec 23;10(1).  [Content Brief]

[2]. Sugiyama T, et al. Royal jelly acid, 10-hydroxy-trans-2-decenoic acid, as a modulator of the innate immune responses. Endocr Metab Immune Disord Drug Targets. 2012 Dec;12(4):368-76.  [Content Brief]

[3]. Sugiyama T, et al. Inhibitory mechanism of 10-hydroxy-trans-2-decenoic acid (royal jelly acid) against lipopolysaccharide- and interferon-β-induced nitric oxide production. Inflammation. 2013 Apr;36(2):372-8.  [Content Brief]

[4]. Ali A M, et al. The effects of royal jelly acid, 10-hydroxy-trans-2-decenoic acid, on neuroinflammation and oxidative stress in astrocytes stimulated with lipopolysaccharide and hydrogen peroxide[J]. Immuno, 2021, 1(3): 212-222.

[5]. Alkhaibari AM, et al. Insecticidal, Antimalarial, and Antileishmanial Effects of Royal Jelly and Its Three Main Fatty Acids, trans-10-Hydroxy-2-decenoic Acid, 10-Hydroxydecanoic Acid, and Sebacic Acid. Evid Based Complement Alternat Med. 2022 Jan 20;2022:7425322.  [Content Brief]

[6]. Shahla J, et al. Comparative immunomodulatory effects of jelly royal and 10-H2DA on experimental autoimmune encephalomyelitis[J]. Gene Reports, 2021, 24: 101217.

[7]. Jenkhetkan W, et al. Antiproliferative and cytotoxic efficacy of 10-hydroxy-2-decenoic acid, compared to doxorubicin, on MCF-7 breast cancer cells[J]. Trends in Sciences, 2021, 18(21): 409-409.