MedChemExpress - Model Thiabendazole - 148-79-8
Thiabendazole is an orally available benzimidazole fungicide with repellent and anticancer activities. Thiabendazole can result in developmental malformations. Thiabendazole can be used for modeling[1][2][3][4][5].MCE products for research use only. We do not sell to patients.
Thiabendazole
MCE China：Thiabendazole
Brand：MedChemExpress (MCE)
Cat. No.HY-B0263
CAS：148-79-8
Synonyms：Tiabendazole; 2-(4-Thiazolyl)benzimidazole
Purity：99.77%
Storage：Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Shipping：Room temperature in continental US; may vary elsewhere.
Description：Thiabendazole is an orally available benzimidazole fungicide with repellent and anticancer activities. Thiabendazole can result in developmental malformations. Thiabendazole can be used for modeling.
In Vitro：Thiabendazole (0/50/100/200/300/400/500 μM, 24/48/72 h) time- and dose-dependently inhibits B16F10 and B16 cells proliferation[2]. Thiabendazole (250 μM, 16 h) inhibits angiogenesis in Xenopus embryos and disrupts newly established vasculature[3].
In Vivo：Thiabendazole (50 mg/kg, 27 days) slows tumor growth in a mouse Xenopus model[3]. Thiabendazole (0/0.5/1/2/4/5/10/20/ mg/L, 0-96 hpf) induces developmental defects in zebrafish through apoptosis, oxidative stress, and changes of PI3K/Akt and MAPK pathwayssup>[4].
IC50 & Target：CDK2 CCNE1 bax Caspase-9 Caspase 3 IL-1β IL-10 IL-6 IL-13 IFN-gamma
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References：
[1]. Budetić M, et al. Review of Characteristics and Analytical Methods for Determination of Thiabendazole. Molecules. 2023 May 6;28(9):3926. [Content Brief]
[2]. Zhang, J., et al., Thiabendazole, a well-known antifungal drug, exhibits anti-metastatic melanoma B16F10 activity via inhibiting VEGF expression and inducing apoptosis. Pharmazie, 2013. 68(12): p. 962-8. [Content Brief]
[3]. Cha, H.J., et al., Evolutionarily repurposed networks reveal the well-known antifungal drug thiabendazole to be a novel vascular disrupting agent. PLoS Biol, 2012. 10(8): p. e1001379. [Content Brief]
[4]. Park J, et al. Developmental defects induced by thiabendazole are mediated via apoptosis, oxidative stress and alteration in PI3K/Akt and MAPK pathways in zebrafish. Environ Int. 2023 Jun;176:107973. [Content Brief]
[5]. Elgebaly SA, et al. Thiabendazole-induced suppression of renal damage in a murine model of autoimmune disease. Am J Pathol. 1984 May;115(2):204-11. [Content Brief]
[6]. Motwadie ME, et al. Modulation of immune functions, inflammatory response, and cytokine production following long-term oral exposure to three food additives; thiabendazole, monosodium glutamate, and brilliant blue in rats. Int Immunopharmacol. 2021 Sep;98:107902. [Content Brief]
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