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Pentagalloylglucose

MCE China：Pentagalloylglucose

Brand：MedChemExpress (MCE)

Cat. No.HY-N0527

CAS：14937-32-7

Synonyms：Penta-O-galloyl-β-D-glucose; 1,2,3,4,6-Pentagalloyl glucose

Purity：99.77%

Storage：Powder -20°C 3 years 4°C 2 years In solvent -80°C 1 year -20°C 6 months

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Pentagalloylglucose (Penta-O-galloyl-β-D-glucose) is an orally active gallic tannin compound and an inducer of apoptosis and autophagy. Pentagalloglucose induces cell apoptosis and autophagy through the GSK3β/β-catenin pathway. Pentagalloglucose has antioxidant, anti mutagenic, anti-inflammatory, anticonvulsant, cardioprotective, anti allergic, cholesterol lowering, and anti-tumor activities.

In Vitro：Pentagalloylglucose (1 μM, 5 days) inhibits the proliferation and survival of breast cancer cells and medulloblastoma cells, with IC50 values of 3.24 μM and 1.47 μM, respectively[1]. Pentagalloylglucose (10-20 μM, 24 h) reduces AGE induced inflammation by activating Nrf2/HO-1 in mesangial cells and inhibiting the JAK2/STAT3 pathway[2]. Pentagalloylglucose (40 μM, 24 h) inhibits the growth and migration of human nasopharyngeal carcinoma cells through the GSK3β/β - catenin pathway, blocks the cell cycle, and induces apoptosis and autophagy[3].

In Vivo：Pentagalloylglucose (10 mg/kg, three times a week, i.v.) enhances tumor sensitivity to PARP inhibitors and radiotherapy by disrupting the PALB2-BRCA2 interaction in MDA-MB-231 xenograft nude mice[1]. Pentagalloylglucose (10, 20 mg/kg, once every two days, i.p.) reduces tumor lung metastasis and exhibits anti-tumor activity in a CNE2 cell xenograft nude mouse model[3]. Pentagalloylglucose (5, 10 mg/kg, 7 days, i.p.) has an improving effect on the Ischemia and reperfusion-induced brain injury in rats[4]. Pentagalloylglucose (10 mg/kg, 28 days, p.o.) increases T regulatory cell populations and inhibits IgE production in ovalbumin sensitized mice through immunosuppressive activity[5].

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References：

[1]. Zeng J, et al. Pentagalloylglucose disrupts the PALB2-BRCA2 interaction and potentiates tumor sensitivity to PARP inhibitor and radiotherapy. Cancer Lett. 2022 Oct 10;546:215851.  [Content Brief]

[2]. Tong J, et al. Pentagalloylglucose reduces AGE-induced inflammation by activating Nrf2/HO-1 and inhibiting the JAK2/STAT3 pathway in mesangial cells. J Pharmacol Sci. 2021 Dec;147(4):305-314.  [Content Brief]

[3]. Fan CW, et al. Pentagalloylglucose suppresses the growth and migration of human nasopharyngeal cancer cells via the GSK3β/β-catenin pathway in vitro and in vivo. Phytomedicine. 2022 Jul 20;102:154192.  [Content Brief]

[4]. Viswanatha GL, et al. Alleviation of transient global ischemia/reperfusion-induced brain injury in rats with 1,2,3,4,6-penta-O-galloyl-β-d-glucopyranose isolated from Mangifera indica. Eur J Pharmacol. 2013 Nov 15;720(1-3):286-93.  [Content Brief]

[5]. Kim YH, et al. 1,2,3,4,6-penta-O-galloyl-β-D-glucopyranose increases a population of T regulatory cells and inhibits IgE production in ovalbumin-sensitized mice. Int Immunopharmacol. 2015 May;26(1):30-6.  [Content Brief]