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MedChemExpressModel Sulpiride - 15676-16-1

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Sulpiride is an orally active dopamine D2/D3 receptor antagonist. Sulpiride is an atypical antipsychotic agent of the benzamide family. Sulpiride can be used in research into anxiety, depression and breast cancer[1][2][3].
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Sulpiride

MCE China:Sulpiride

Brand:MedChemExpress (MCE)

Cat. No.HY-B1019

CAS:15676-16-1

Purity:99.28%

Storage:Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year

Shipping:Room temperature in continental US; may vary elsewhere.

Description:Sulpiride is an orally active dopamine D2/D3 receptor antagonist. Sulpiride is an atypical antipsychotic agent of the benzamide family. Sulpiride can be used in research into anxiety, depression and breast cancer.

In Vitro:Dopamine, Alzheimer's, depression, Anxiety, Sprague-Dawley rats, NMRI mouse, Parkinson’s disease, psychosis, MCF-7/Adr, Breast cancer, Dexamethasone, Drug combination,MCF-7/Adr, Cancer stem-like cells (CSCs)

In Vivo:Sulpiride (50 mg/kg; Subcutaneous injection; Single dose) can increase the dopamine level in Sprague-Dawley rats[2]. Sulpiride (5-20 mg/kg; Intraperitoneal injection; Single dose) improves memory, but induces anxiety in Parkinson's disease (PD) mice at a dose of 20 mg/kg[3]. Sulpiride (25-100 mg/kg; Oral gavage; Once daily for 18 days) can enhance the anti-tumor activity of dexamethasone (DEX) (HY-14648) (1 and 8 mg/kg) in combination with dexamethasone in nu/nu nude mice bearing MCF-7/Adr xenografts.Without significant toxicity to organs[4].

IC50 & Target:D2 Receptor D3 Receptor

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References:

[1]. Rüther, E et al. Antidepressant action of sulpiride. Results of a placebo-controlled double-blind trial. Pharmacopsychiatry vol. 32,4 (1999): 127-35.  [Content Brief]

[2]. Jaworski, J N et al. Effect of dopamine D2/D3 receptor antagonist sulpiride on amphetamine-induced changes in striatal extracellular dopamine. European journal of pharmacology vol. 418,3 (2001): 201-6.  [Content Brief]

[3]. Zarrindast, Mohammad-Reza et al. Synergistic effect between quinpirole and L-NAME as well as sulpiride and L-arginine on the modulation of anxiety and memory processes in the 6-OHDA mouse model of Parkinson's disease: An isobologram analysis. Neurobiology of learning and memory vol. 186 (2021): 107538.  [Content Brief]

[4]. Li, Jian et al. Dopamine D2 receptor antagonist sulpiride enhances dexamethasone responses in the treatment of drug-resistant and metastatic breast cancer. Acta pharmacologica Sinica vol. 38,9 (2017): 1282-1296.  [Content Brief]

Brand introduction:
•   MCE (MedChemExpress) has a global exclusive compound library of more than 200 kinds, and we are committed to providing the most comprehensive range of high-quality small molecule active compounds for scientific research customers around the world;
•   More than 50,000 highly selective inhibitors and agonists are involved in various popular signaling pathways and disease areas;
•   The products cover a variety of recombinant proteins, peptides, commonly used kits, more PROTAC, ADC and other characteristic products, widely used in new drug research and development, life science and other scientific research projects;
•   Provide virtual screening, ion channel screening, metabolomics analysis detection analysis, drug screening and other professional technical services;
•   It has a professional experimental center and strict quality control and verification system;
•   Provide LC/MS, NMR, HPLC, chiral analysis, elemental analysis and other quality inspection reports to ensure the high purity and high quality of products;
•   The biological activity of the products has been verified by the experiments of customers in various countries;
•   A variety of top journals such as Nature, Cell, Science and pharmaceutical patents have included the scientific research results of MCE customers;
•   Our professional team tracks the latest pharmaceutical and life science research and provides you with the latest active compounds in the world;
•   It has established long-term cooperation with the world's major pharmaceutical companies and well-known scientific research institutions。