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MedChemExpressModel Clivatuzumab - 1622075-09-5

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Clivatuzumab is a humanized anti-mucin monoclonal antibody targeting an epitope in the MUC1 antigen expressed in most pancreatic cancers[1].
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Clivatuzumab

MCE China:Clivatuzumab

Brand:MedChemExpress (MCE)

Cat. No.HY-P99968

CAS:1622075-09-5

Purity:99.0%

Storage:Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping:Shipping with dry ice.

Description:Clivatuzumab is a humanized anti-mucin monoclonal antibody targeting an epitope in the MUC1 antigen expressed in most pancreatic cancers.

In Vitro:Clivatuzumab demonstrates high specificity for pancreatic ductal adenocarcinoma (PDAC) with little to no reactivity towards normal and benign, non-neoplastic, pancreatic tissues, although it does show limited reactivity (approximately 10% of all specimens examined) with adenocarcinomas originating in certain other organs (e.g., stomach, colon, lung)[1].

Species:Humanized

Isotype:Human IgG1 kappa

Recommend Isotype Controls:Human IgG1 kappa, Isotype Control

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References:

[1]. Gold DV, et al. Mapping PAM4 (clivatuzumab), a monoclonal antibody in clinical trials for early detection and therapy of pancreatic ductal adenocarcinoma, to MUC5AC mucin. Mol Cancer. 2013 Nov 20;12(1):143.  [Content Brief]

Brand introduction:
•   MCE (MedChemExpress) has a global exclusive compound library of more than 200 kinds, and we are committed to providing the most comprehensive range of high-quality small molecule active compounds for scientific research customers around the world;
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•   The biological activity of the products has been verified by the experiments of customers in various countries;
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•   It has established long-term cooperation with the world's major pharmaceutical companies and well-known scientific research institutions。