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MedChemExpressModel Diethylcarbamazine citrate - 1642-54-2

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Diethylcarbamazine citrate is an orally active anthropoidal compound. Diethylcarbamazine citrate is an inhibitor of arachidonic acid metabolism of filaria microfilaria. Diethylcarbamazine citrate has anti-inflammatory and antiparasitic activity[1][2][3].
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Diethylcarbamazine citrate

MCE China:Diethylcarbamazine citrate

Brand:MedChemExpress (MCE)

Cat. No.HY-12642

CAS:1642-54-2

Purity:99.95%

Storage:4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Shipping:Room temperature in continental US; may vary elsewhere.

Description:Diethylcarbamazine citrate is an orally active anthropoidal compound. Diethylcarbamazine citrate is an inhibitor of arachidonic acid metabolism of filaria microfilaria. Diethylcarbamazine citrate has anti-inflammatory and antiparasitic activity.

In Vivo:Diethylcarbamazine citrate (250 mg/kg intravenously, single dose) induces a sharp early decrease in mf count in albino-infected rats, followed by an increase[2]. Diethylcarbamazine citrate (50 mg/kg orally, twice weekly) can improve insulin resistance in obese mice induced by high-fat diet by regulating adipose tissue inflammation[3].

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References:

[1]. El-Shahawi GA, et al. Setaria equina: in vivo effect of diethylcarbamazine citrate on microfilariae in albino rats. Exp Parasitol. 2010 Dec;126(4):603-10.  [Content Brief]

[2]. Abdul-Razek N, et al. Enhancement of Anti-allergic Effect of Diethylcarbamazine Citrate in Asthmatic Mouse Model: Testing of Anti-drug Antibodies and Quercetin. Iran J Allergy Asthma Immunol. 2020 Aug 25;19(4):373-385.  [Content Brief]

[3]. Abdel-Latif M. Diethylcarbamazine citrate ameliorates insulin resistance in high-fat diet-induced obese mice via modulation of adipose tissue inflammation. Int Immunopharmacol. 2015 Dec;29(2):607-612.  [Content Brief]

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