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MedChemExpressModel Fentiazac - 18046-21-4

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Fentiazac, alkanoic acid derivative, is an orally active non-steroidal anti-inflammatory agent, with analgesic, antipyretic and platelet anti-aggregation activity. Fentiazac can be used to research inflammatory diseases such as rheumatoid arthritis, osteoarthritis and tendinitis[1][2][3].
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Fentiazac

MCE China:Fentiazac

Brand:MedChemExpress (MCE)

Cat. No.HY-118752

CAS:18046-21-4

Purity:99.87%

Storage:Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month

Shipping:Room temperature in continental US; may vary elsewhere.

Description:Fentiazac, alkanoic acid derivative, is an orally active non-steroidal anti-inflammatory agent, with analgesic, antipyretic and platelet anti-aggregation activity. Fentiazac can be used to research inflammatory diseases such as rheumatoid arthritis, osteoarthritis and tendinitis.

In Vivo:Fentiazac is well tolerated after repeated oral administration in rats, monkeys and dogs; and no significant modifications in the heart and bone marrow function, as well as blood chemistry[1]. Tolerance of Fentiazac in rat, monkey and dog[1]. Species Tolerant dosage Tolerant administration day Rat 0-50 mg/kg/day 90 days Red pated monkey 40 mg/kg/day 90 days 0-30 mg/kg/day 180 days African green monkey 0-8 mg/kg/day 79 to 93 days dog 16.6 mg/kg/day 180 days

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References:

[1]. Emilio Marmo, et al. Experimental and clinical pharmacology of fentiazac, a new, non-steroidal anti-inflammatory agent. Current Medical Research and Opinion.Volume 6, 1979 - Issue sup2.

[2]. Gabor Katona, et al. Efficacy and tolerability of fentiazac in rheumatoid arthritis: Double-blind study versus indomethacin. Current Medical Research and Opinion. Volume 6, 1979 - Issue sup2.

[3]. Famaey JP, Gaci O, Ginsberg F. Fentiazac in the treatment of osteoarthritis and tendinitis. Curr Med Res Opin. 1983;8(9):675-81.  [Content Brief]

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