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MedChemExpress - Model Cortistatin-14 - ...

MedChemExpress - Model Cortistatin-14 - 186901-48-4

Cortistatin-14 is a neuropeptide that shares structural similarities with somatostatin, working by binding to somatostatin receptors (sst1-sst5). Cortistatin-14 (TFA) has anticonvulsant, neuroprotective effects, and significant anti-inflammatory properties[1][2][3].

Cortistatin-14

MCE China：Cortistatin-14

Brand：MedChemExpress (MCE)

Cat. No.HY-P1932

CAS：186901-48-4

Purity：99.21%

Storage：Sealed storage, away from moisture Powder -80°C 2 years -20°C 1 year *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Cortistatin-14 is a neuropeptide that shares structural similarities with somatostatin, working by binding to somatostatin receptors (sst1-sst5). Cortistatin-14 (TFA) has anticonvulsant, neuroprotective effects, and significant anti-inflammatory properties.

In Vitro：Cortistatin-14 (100-10000 nM, 8-24 min) reduces the release of calcitonin gene-related peptide from peripheral sensory nerve endings in the isolated trachea of rats induced by capsaicin (HY-10448) [1]. CST-14 (0.1-10 μg/mL, 8 h) significantly decreases the secretion of the cytokine IL-1β in mouse peritoneal macrophages [1].

In Vivo：Cortistatin-14 (10-250 μg/kg; injected in the footpad or intraperitoneal injection; six times a day) reduces acute neurogenic plasma protein leakage in the hind paw skin of rats caused by mustard oil, as well as carrageenan-induced paw edema in mice, mechanical hyperalgesia, the production of IL-1β and tumor necrosis factor-α, and mild heat injury-induced thermal hyperalgesia[1]. Cortistatin-14 (10 μg; intravenous injection; single dose) plays a regulatory role in the pituitary secretion of male rats[2]. Cortistatin-14 (1-10 nM, intracerebroventricular injection; single dose) has anticonvulsant and neuroprotective effects in rats by binding to somatostatin receptors, which leads to a reduction in the release of excitatory neurotransmitters[3].

IC50 & Target：SSTR1 SSTR2 SSTR3 SSTR4 SSTR5

Sequence：{Pro}{Cys}{Lys}{Asn}{Phe}{Phe}{Trp}{Lys}{Thr}{Phe}{Ser}{Ser}{Cys}{Lys}-NH2 (Disulfide bridge: Cys2-Cys13)

References：

[1]. Markovics A, et al. Comparison of the anti-inflammatory and anti-nociceptive effects of cortistatin-14 and somatostatin-14 in distinct in vitro and in vivo model systems. J Mol Neurosci. 2012 Jan;46(1):40-50. [Content Brief]

[2]. Baranowska B, et al. Cortistatin and pituitary hormone secretion in rat. J Physiol Pharmacol. 2009 Mar;60(1):151-6. [Content Brief]

[3]. Braun H, et al. Protective effects of cortistatin (CST-14) against kainate-induced neurotoxicity in rat brain. Brain Res. 1998 Aug 24;803(1-2):54-60. [Content Brief]

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