MedChemExpress -Model Mirikizumab -1884201-71-1
Mirikizumab (LY3074828) is a humanized IgG4 monoclonal antibody that targets the p19 subunit of interleukin 23 (IL-23). Mirikizumab binds to human and monkey IL-23 with high affinity, with Kd values of 21 pM and 55 pM, respectively. By inhibiting the binding of IL-23 to IL-23R, Mirikizumab modulates the immune response and holds potential for research in ulcerative colitis and Crohn's disease[1][2].MCE products for research use only. We do not sell to patients.
Mirikizumab
MCE China：Mirikizumab
Brand：MedChemExpress (MCE)
Cat. No.HY-P99737
CAS：1884201-71-1
Synonyms：LY3074828
Purity：98.15%
Storage：Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping：Shipping with dry ice.
Description：Mirikizumab (LY3074828) is a humanized IgG4 monoclonal antibody that targets the p19 subunit of interleukin 23 (IL-23). Mirikizumab binds to human and monkey IL-23 with high affinity, with Kd values of 21 pM and 55 pM, respectively. By inhibiting the binding of IL-23 to IL-23R, Mirikizumab modulates the immune response and holds potential for research in ulcerative colitis and Crohn's disease.
In Vitro：Mirikizumab (4.4 pM - 800 nM, 48 h) can completely neutralize IL-17A production induced by human and cynomolgus monkey IL-23 in mouse splenocytes, with IC50 values of 82 pM and 120 pM for human and cynomolgus monkey IL-23, respectively[2]. Mirikizumab (0.1 ng/mL - 1 μg/mL, 48 h) can completely inhibit IL-17 secretion induced by anti-CD3/anti-CD28 and IL-23 in two different human peripheral blood mononuclear cell (PBMC) preparations, with IC50 values of 22 μg/mL and 29 μg/mL for these PBMC preparations, respectively[2]. Mirikizumab (50 or 500 ng/mL, 48 h) does not affect IL-12-induced STAT4 phosphorylation in Kit225 and TALL-104 cells[2].
In Vivo：Mirikizumab (7.5 mg/kg, i.p., administered at 9, 16, and 32 hours) exhibits anti-inflammatory activity in an acute systemic mouse model[2].
Species：Humanized
Isotype：Human IgG4 kappa
Recommend Isotype Controls：Human IgG4 (S228P) kappa, Isotype Control
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References：
[2]. Steere B, et al. Generation and Characterization of Mirikizumab, a Humanized Monoclonal Antibody Targeting the p19 Subunit of IL-23. J Pharmacol Exp Ther. 2023 Nov;387(2):180-187. Steere B, Beidler C, Martin A, Bright S, Kikly K, Benschop RJ. Generation and Characterization of Mirikizumab, a Humanized Monoclonal Antibody Targeting the p19 Subunit of IL-23. J Pharmacol Exp Ther. 2023 Nov;387(2):180-187. [Content Brief]
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