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MedChemExpressModel MC-Val-Cit-PAB-duocarmycin chloride - 2055896-98-3

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MC-Val-Cit-PAB-duocarmycin chloride is a agent-linker conjugate for ADC with potent antitumor activity by using Duocarmycin (a DNA minor groove binding alkylating agent), linked via the ADC linker MC-Val-Cit-PAB.
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MC-Val-Cit-PAB-duocarmycin chloride

MCE China:MC-Val-Cit-PAB-duocarmycin chloride

Brand:MedChemExpress (MCE)

Cat. No.HY-128904

CAS:2055896-98-3

Purity:98.77%

Storage:-80°C, protect from light, stored under nitrogen *The compound is unstable in solutions, freshly prepared is recommended.

Shipping:Shipping with dry ice.

Description:MC-Val-Cit-PAB-duocarmycin chloride is a agent-linker conjugate for ADC with potent antitumor activity by using Duocarmycin (a DNA minor groove binding alkylating agent), linked via the ADC linker MC-Val-Cit-PAB.

In Vitro:Antibody-drug conjugates (ADCs) carry a highly potent small-molecule toxin covalently connected on the antibody via a proper linker. For therapeutic ADCs in cancer treatment, the antibody targets specific antigen of tumor cell surface with high binding affinity, thereafter the intact ADC was internalized into the tumor cells with the antigen and digested in the lysosome to release the antitumor toxin[1].

IC50 & Target:Duocarmycins

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References:

[1]. Staben LR, et al. Targeted drug delivery through the traceless release of tertiary and heteroaryl amines from antibody-drug conjugates. Nat Chem. 2016 Dec;8(12):1112-1119.  [Content Brief]

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