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MedChemExpress - Model Dendrobine - ...

MedChemExpress - Model Dendrobine - 2115-91-5

Dendrobine is an alkaloid isolated from Dendrobium nobile. Dendrobine possesses antiviral activity against influenza A viruses, with IC50s of 3.39 μM, 2.16 μM and 5.32 μM for A/FM-1/1/47 (H1N1), A/Puerto Rico/8/34 H274Y (H1N1) and A/Aichi/2/68 (H3N2), respectively. Dendrobine activates the JNK/p38/Nrf2 signaling pathway. Dendrobine exhibits antiviral, antitumor, anti-inflammatory, and neuroprotective properties[1][2][3][4][5].

Dendrobine

MCE China：Dendrobine

Brand：MedChemExpress (MCE)

Cat. No.HY-N0638

CAS：2115-91-5

Purity：99.92%

Storage：4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Dendrobine is an alkaloid isolated from Dendrobium nobile. Dendrobine possesses antiviral activity against influenza A viruses, with IC50s of 3.39 μM, 2.16 μM and 5.32 μM for A/FM-1/1/47 (H1N1), A/Puerto Rico/8/34 H274Y (H1N1) and A/Aichi/2/68 (H3N2), respectively. Dendrobine activates the JNK/p38/Nrf2 signaling pathway. Dendrobine exhibits antiviral, antitumor, anti-inflammatory, and neuroprotective properties.

In Vitro：Dendrobine (1-10 μg/mL, 24 h) inhibits the cell viability, migration and invasion of cancer cell A549[2]. Dendrobine (0.001-0.1 µM, 36 h) inhibits Aβ1−42-induced apoptosis in cell PC12 by inhibiting the activation of CDK5, and regulating the apoptosis-related proteins[3]. Dendrobine (0.01-1 µM, 36 h) inhibits the ROS and MDA generation, activates the antioxidant enzymes SOD, CAT and GSH-Px, thereby exhibiting antioxidant efficacy in HACAT cell[4].

In Vivo：Dendrobine (25 mg/kg, ip for 14 days) exhibits antitumor efficacy in A549 xenograft mouse models[2]. Dendrobine (20 mg/kg, po for 20 days) ameliorates gestational diabetes mellitus (GDM) in mouse models[5].

IC50 & Target：IC50: 3.39 μM (A/FM-1/1/47), 2.16 μM (A/Puerto Rico/8/34 H274Y), 5.32 μM (A/Aichi/2/68)[1] Cellular Effect Cell Line Type Value Description References

References：

[1]. Li R, et al. Anti-influenza A Virus Activity of Dendrobine and Its Mechanism of Action. J Agric Food Chem. 2017 May 10;65(18):3665-3674. [Content Brief]

[2]. Kim YR, et al., Dendrobine Inhibits γ-Irradiation-Induced Cancer Cell Migration, Invasion and Metastasis in Non-Small Cell Lung Cancer Cells. Biomedicines. 2021 Aug 3;9(8):954. [Content Brief]

[3]. Zhang CC, et al., Two new alkaloids from Dendrobium nobile Lindl. exhibited neuroprotective activity, and dendrobine alleviated Aβ1-42 -induced apoptosis by inhibiting CDK5 activation in PC12 cells. Drug Dev Res. 2023 Apr;84(2):262-274. [Content Brief]

[4]. Yue Q, et al., Dendrobine protects HACAT cells from H2O2-induced oxidative stress and apoptosis damage via Nrf2/Keap1/ARE signaling pathway. Toxicol Appl Pharmacol. 2022 Nov 1;454:116217. [Content Brief]

[5]. Feng Y, et al., Dendrobine attenuates gestational diabetes mellitus in mice by inhibiting Th17 cells. Basic Clin Pharmacol Toxicol. 2021 Mar;128(3):379-385. [Content Brief]

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