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8-Gingerol

MCE China：8-Gingerol

Brand：MedChemExpress (MCE)

Cat. No.HY-N0447

CAS：23513-08-8

Purity：99.82%

Storage：-20°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Shipping：Room temperature in continental US; may vary elsewhere.

Description：8-Gingerol can be found in the rhizome of ginger (Z. officinale) and has oral bioactivity. It activates TRPV1, with an EC50 value of 5.0 µM. 8-Gingerol inhibits COX-2 and also suppresses the growth of H. pylori in vitro. Additionally, 8-Gingerol exhibits anticancer, antioxidant, and anti-inflammatory properties by inhibiting the epidermal growth factor receptor (EGFR) and modulating its downstream STAT3/ERK pathway to suppress the proliferation, migration, and invasion of colorectal cancer cells. 8-Gingerol also exerts immunosuppressive effects by inhibiting oxidative stress, inducing cell cycle arrest, promoting apoptosis, and regulating autophagy. Furthermore, 8-Gingerol has cardioprotective effects. 8-Gingerol is promising for research in the fields of cancer, infection, immunosuppression, and cardiovascular diseases.

In Vitro：8-Gingerol (0-70 µM, 24-72 hours) can inhibit the proliferation of HCT116 and DLD1 colorectal cancer cells, induce G0/G1 phase cell cycle arrest, and significantly promote apoptosis in HCT116 cells[3]. 8-Gingerol (0-70 µM, 48 hours) significantly inhibits the migration and invasion abilities of the cells, and its effect is dependent on the EGFR/STAT3/ERK pathway[3]. 8-Gingerol (100 µM, 48 hours) can reduce the effective concentration of 5-FU in HCT116 and DLD1 colorectal cancer cells, and in combination treatment, it may help reduce the toxicity of 5-FU[3]. 8-Gingerol (40, 80 µg/mL, 24 hours) significantly inhibits the LPS (HY-D1056) and Concanavalin A (HY-P2149) induced splenocyte proliferation, exhibiting immunosuppressive effects[4]. 8-Gingerol (10, 20 µM, 48 hours) inhibits autophagy and apoptosis in myocardial fibrosis by regulating the PI3K/Akt/mTOR signaling pathway, showing significant cardioprotective effects[5].

In Vivo：8-Gingerol (50, 100 mg/kg, i.p., once daily for 7 days) can suppress the humoral and cellular immune responses in mice, likely by directly inhibiting activated T cells and B cells[4]. 8-Gingerol (10, 20 mg/kg, i.p., once daily for 14 days) improves ISO-induced myocardial fibrosis in mice by regulating the PI3K/Akt/mTOR signaling pathway, inhibiting oxidative stress, apoptosis, and autophagy[5].

IC50 & Target：MMP-9 Caspase-9

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References：

[1]. Dedov, V.N., et al. Gingerols: a novel class of vanilloid receptor (VR1) agonists. Br. J. Pharmacol. 137(6), 793-798 (2002).  [Content Brief]

[2]. Chrubasik, S., et al. Zingiberis rhizoma: A comprehensive review on the ginger effect and efficacy profiles. Phytomedicine 12(9), 684-701 (2005).  [Content Brief]

[3]. Hu SM, et al. 8‑Gingerol regulates colorectal cancer cell proliferation and migration through the EGFR/STAT/ERK pathway. Int J Oncol. 2020 Jan;56(1):390-397.  [Content Brief]

[4]. Lu J, et al. Immunosuppressive activity of 8-gingerol on immune responses in mice. Molecules. 2011 Mar 22;16(3):2636-45.  [Content Brief]

[5]. Xue Y, et al. 8-Gingerol Ameliorates Myocardial Fibrosis by Attenuating Reactive Oxygen Species, Apoptosis, and Autophagy via the PI3K/Akt/mTOR Signaling Pathway. Front Pharmacol. 2021 Jul 28;12:711701.  [Content Brief]