- Home
- Companies
- MedChemExpress LLC (MCE)
- Products
- MedChemExpress - Model Fulzerasib - ...
MedChemExpress - Model Fulzerasib - 2641747-54-6
Fulzerasib (GFH925) is an irreversible KRAS G12C inhibitor, has a synergistic anti-cancer effect with cetuximab (HY-P9905).[1][2].MCE products for research use only. We do not sell to patients.
Fulzerasib
MCE China:Fulzerasib
Brand:MedChemExpress (MCE)
Cat. No.HY-152848
CAS:2641747-54-6
Synonyms:IBI351; GFH925
Purity:99.60%
Storage:Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Shipping:Room temperature in continental US; may vary elsewhere.
Description:Fulzerasib (GFH925) is an irreversible KRAS G12C inhibitor, has a synergistic anti-cancer effect with cetuximab (HY-P9905)..
In Vitro:Fulzerasib covalently inhibits GDP/GTP nucleotide exchange on KRAS G12C (IC50: 29 nM), locking KRAS in its inactive GDP-bound state (RAS-GTP IC50: 74 nM), thereby blocking the KRAS signaling pathway (pERK IC50: 37 nM)[1]. Fulzerasib inhibits the growth of tumor cell lines carrying the KRAS G12C mutation (IC50: 2-20 nM)[1].
In Vivo:Fulzerasib shows strong anti-tumor activity in various models, including the pancreatic cancer cell line MIA Paca-2 CDX, human lung adenocarcinoma NCI-H358 CDX, patient-derived xenograft colon adenocarcinoma SW837 CDX, and lung cancer LU2529 PDX[1].
IC50 & Target:KRAS(G12C)
Hot selling product:Guanosine | Narirutin | Chrysophanol | Ulinastatin | Zaprinast | Pipecolic acid | ML-9 | Tiotropium (Bromide) | Spesolimab | 5-Aminolevulinic acid-13C-15 (hydrochloride)
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides
References:
[1]. Rafael Rosell, et al. KRAS G12C-mutant driven non-small cell lung cancer (NSCLC). Crit Rev Oncol Hematol. 2024 Mar:195:104228. [Content Brief]
Brand introduction:
• MCE (MedChemExpress) has a global exclusive compound library of more than 200 kinds, and we are committed to providing the most comprehensive range of high-quality small molecule active compounds for scientific research customers around the world;
• More than 50,000 highly selective inhibitors and agonists are involved in various popular signaling pathways and disease areas;
• The products cover a variety of recombinant proteins, peptides, commonly used kits, more PROTAC, ADC and other characteristic products, widely used in new drug research and development, life science and other scientific research projects;
• Provide virtual screening, ion channel screening, metabolomics analysis detection analysis, drug screening and other professional technical services;
• It has a professional experimental center and strict quality control and verification system;
• Provide LC/MS, NMR, HPLC, chiral analysis, elemental analysis and other quality inspection reports to ensure the high purity and high quality of products;
• The biological activity of the products has been verified by the experiments of customers in various countries;
• A variety of top journals such as Nature, Cell, Science and pharmaceutical patents have included the scientific research results of MCE customers;
• Our professional team tracks the latest pharmaceutical and life science research and provides you with the latest active compounds in the world;
• It has established long-term cooperation with the world's major pharmaceutical companies and well-known scientific research institutions。