MedChemExpress - Model SC-435 - 289037-67-8

FromMedChemExpress LLC (MCE)

SC-435 is an orally effective apical sodium codependent bile acid transporter (ASBT) inhibitor. SC-435 effectively removes neurotoxic bile acids and ammonia from the blood by inhibiting intestinal ASBT, thereby alleviating liver and brain damage caused by liver failure. SC-435 can alter hepatic cholesterol metabolism and lower plasma low-density lipoprotein-cholesterol concentrations[1] [2] [3].

SC-435

MCE China：SC-435

Brand：MedChemExpress (MCE)

Cat. No.HY-129982

CAS：289037-67-8

Purity：98.73%

Storage：4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Shipping：Room temperature in continental US; may vary elsewhere.

Description：SC-435 is an orally effective apical sodium codependent bile acid transporter (ASBT) inhibitor. SC-435 effectively removes neurotoxic bile acids and ammonia from the blood by inhibiting intestinal ASBT, thereby alleviating liver and brain damage caused by liver failure. SC-435 can alter hepatic cholesterol metabolism and lower plasma low-density lipoprotein-cholesterol concentrations .

In Vivo：SC-435 (10 μg/1 g; Oral administration; 5-16 weeks) reduces liver and brain damage due to liver failure in mouse models of chronic liver disease induced by Streptozotocin (HY-13753) and acute liver failure induced by Azoxymethane (HY-111375)[2]. SC-435 (0.03-0.1 g/100 g; Oral administration; 12 weeks) alone or in combination with Simvastatin (HY-17502) reduces LDL cholesterol concentration by altering hepatic cholesterol homeostasis and intravascular lipoprotein processing in guinea pig models of endogenous hypercholesterolemia[3].

IC50 & Target：Bile acid transporter[1] In Vivo SC-435 (10 μg/1 g; Oral administration; 5-16 weeks) reduces liver and brain damage due to liver failure in mouse models of chronic liver disease induced by Streptozotocin (HY-13753) and acute liver failure induced by Azoxymethane (HY-111375)[2]. SC-435 (0.03-0.1 g/100 g; Oral administration; 12 weeks) alone or in combination with Simvastatin (HY-17502) reduces LDL cholesterol concentration by altering hepatic cholesterol homeostasis and intravascular lipoprotein processing in guinea pig models of endogenous hypercholesterolemia[3]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Streptozotocin (HY-13753) or Azoxymethane (HY-111375) treated male C57BL/6J mice (25-30 g)[2]

References：

[1]. West KL, et, al. 1-[4-[4[(4R,5R)-3,3-Dibutyl-7-(dimethylamino)-2,3,4,5-tetrahydro-4-hydroxy-1,1-dioxido-1-benzothiepin-5-yl]phenoxy]butyl]-4-aza-1-azoniabicyclo[2.2.2]octane methanesulfonate (SC-435), an ileal apical sodium-codependent bile acid transporter inhibitor alters hepatic cholesterol metabolism and lowers plasma low-density lipoprotein-cholesterol concentrations in guinea pigs. J Pharmacol Exp Ther. 2002 Oct;303(1):293-9. [Content Brief]

[2]. Xie G, et al. Dysregulated bile acid signaling contributes to the neurological impairment in murine models of acute and chronic liver failure. EBioMedicine. 2018 Nov;37:294-306. [Content Brief]

[3]. West KL, et al. SC-435, an ileal apical sodium-codependent bile acid transporter inhibitor alters mRNA levels and enzyme activities of selected genes involved in hepatic cholesterol and lipoprotein metabolism in guinea pigs. J Nutr Biochem. 2005 Dec;16(12):722-8. [Content Brief]

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