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MedChemExpress - Model Hydralazine ...

MedChemExpress - Model Hydralazine hydrochloride - 304-20-1

Hydralazine hydrochloride is an antihypertensive agent. Hydralazine hydrochloride can inhibit mitochondrial fission and human peritoneal mesothelial cell proliferation. Hydralazine hydrochloride has immunomodulation and anti-migratory effect. Hydralazine hydrochloride activates the intrinsic pathway of apoptosis and causes DNA damage[1][2][3][4][5].

Hydralazine hydrochloride

MCE China：Hydralazine hydrochloride

Brand：MedChemExpress (MCE)

Cat. No.HY-B0464

CAS：304-20-1

Purity：99.97%

Storage：4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Hydralazine hydrochloride is an antihypertensive agent. Hydralazine hydrochloride can inhibit mitochondrial fission and human peritoneal mesothelial cell proliferation. Hydralazine hydrochloride has immunomodulation and anti-migratory effect. Hydralazine hydrochloride activates the intrinsic pathway of apoptosis and causes DNA damage.

In Vitro：Hydralazine hydrochloride (40-600 μM, 24-48 h) induces caspase-dependent apoptosis and activates mitochondrial apoptotic events in leukemic T cells[1]. Hydralazine hydrochloride (1 μM, 40 min) prevents H2O2-induced mitochondrial fragmentation and depolarization in ATCC-CCL2 cells[2]. Hydralazine hydrochloride (3-100 μg/mL, 1-5 days) inhibits human peritoneal mesothelial cell proliferation[3].

In Vivo：Hydralazine hydrochloride (5 mg/kg, Intraperitoneal injection, once a day for 4-6 weeks) plays an immunomodulation role of pro-regeneration in Spinal cord injury mice[4]. Hydralazine hydrochloride (14 mg/kg, supplemented in drinking water for 15 days) reduces leukocyte migration in spontaneously hypertensive and normotensive rats[5].

IC50 & Target：Bcl-2 Bcl-xL Caspase-8 Caspase-9 Caspase 3

References：

[1]. Fang C C, et al. Hydralazine inhibits human peritoneal mesothelial cell proliferation and collagen synthesis [J]. Nephrology Dialysis Transplantation, 1996, 11(11): 2276-2281. [Content Brief]

[2]. Kalkhoran S B, et al. Hydralazine protects the heart against acute ischaemia/reperfusion injury by inhibiting Drp1-mediated mitochondrial fission [J]. Cardiovascular Research, 2022, 118(1): 282-294. [Content Brief]

[3]. Ruiz-Magaña M J, et al. The antihypertensive drug hydralazine activates the intrinsic pathway of apoptosis and causes DNA damage in leukemic T cells [J]. Oncotarget, 2016, 7(16): 21875. [Content Brief]

[4]. Quan X, et al. Hydralazine plays an immunomodulation role of pro-regeneration in a mouse model of spinal cord injury [J]. Experimental Neurology, 2023, 363: 114367. [Content Brief]

[5]. Rodrigues S F, et al. Hydralazine reduces leukocyte migration through different mechanisms in spontaneously hypertensive and normotensive rats [J]. European journal of pharmacology, 2008, 589(1-3): 206-214. [Content Brief]

Brand introduction:
•   MCE (MedChemExpress) has a global exclusive compound library of more than 200 kinds, and we are committed to providing the most comprehensive range of high-quality small molecule active compounds for scientific research customers around the world；
•   More than 50,000 highly selective inhibitors and agonists are involved in various popular signaling pathways and disease areas；
•   The products cover a variety of recombinant proteins, peptides, commonly used kits, more PROTAC, ADC and other characteristic products, widely used in new drug research and development, life science and other scientific research projects；
•   Provide virtual screening, ion channel screening, metabolomics analysis detection analysis, drug screening and other professional technical services；
•   It has a professional experimental center and strict quality control and verification system；
•   Provide LC/MS, NMR, HPLC, chiral analysis, elemental analysis and other quality inspection reports to ensure the high purity and high quality of products；
•   The biological activity of the products has been verified by the experiments of customers in various countries；
•   A variety of top journals such as Nature, Cell, Science and pharmaceutical patents have included the scientific research results of MCE customers；
•   Our professional team tracks the latest pharmaceutical and life science research and provides you with the latest active compounds in the world；
•   It has established long-term cooperation with the world's major pharmaceutical companies and well-known scientific research institutions。