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MedChemExpress - Model Deferiprone - ...

MedChemExpress - Model Deferiprone - 30652-11-0

Deferiprone is a potent, orally active, brain-penetrant, cell-penetrant, skin-permeable, free iron chelating agent. Deferiprone inhibits the proliferation and migration, and stimulates apoptosis in tumor cell. Deferiprone has antianemic, neuroprotective, anti-inflammatory, antioxidant, and antidotal activity. Deferiprone can be used in cancer, cardiovascular disease, infection, inflammation, and neurological disease study[1][2][3][4][5][6][7][8].

Deferiprone

MCE China：Deferiprone

Brand：MedChemExpress (MCE)

Cat. No.HY-B0568

CAS：30652-11-0

Purity：99.97%

Storage：Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Deferiprone is a potent, orally active, brain-penetrant, cell-penetrant, skin-permeable, free iron chelating agent. Deferiprone inhibits the proliferation and migration, and stimulates apoptosis in tumor cell. Deferiprone has antianemic, neuroprotective, anti-inflammatory, antioxidant, and antidotal activity. Deferiprone can be used in cancer, cardiovascular disease, infection, inflammation, and neurological disease study.

In Vitro：Deferiprone (66-660 μM, 48-96 h) has a significant inhibitory effect on proliferation in TRAMP-C2, Myc-CaP, and 22rv1 cells[1]. Deferiprone (100 μM, up to 192 h) inhibits cell migration in TRAMP-C2, Myc-CaP, and 22rv1 cells[1]. Deferiprone (100 μM, 24 h) reduces the expression and activity of m-Acon in TRAMP-C2, Myc-CaP, and 22rv1 cells[1]. Deferiprone (up to 1μM, 0.5-24 h) decreases the free iron in thalassemic red blood cells[2]. Deferiprone (10 mins) inhibits human platelet aggregation stimulated by AA and ADP and epinephrine and collagen, with the IC50 values of 0.24, 0.25, 3.36 and 3.73 mM, respectively[3]. Deferiprone (0.1-3.2 μM, 5 mins) inhibits COX-1 activity with the IC50 value of 0.33 μM[3]. Deferiprone (4 mM, 5 mins) preventes ADP-induced formation of cAMP[3]. Deferiprone (156.25 μg/mL, 24 h) enhances survival rate and reduces LDH Levels and displays normal cell morphology in aged Fibroblasts[4]. Deferiprone (25μM, 6 h) amplifies the antibacterial activity of conventional antibiotics against S. epidermidis[5].

In Vivo：Deferiprone (100 mg/kg/daily for i.g., 4 weeks) has a neuroprotective effect in the rTg(tauP301L)4510 mouse model of tauopathy[6]. Deferiprone (50-200 mg/kg/daily for p.o., 5-10 day) reduces the nephrotoxicity in Cisplatin (HY-17394)-induced rat acute renal failure[7]. Deferiprone (13.82, 27.64 mg/kg/d for i.g., 4 weeks) exhibits anti- apoptosis and neuroprotective activity in rat Alzheimer’s disease model[8].

References：

[1]. Rui V. Simões, Inhibition of prostate cancer proliferation by Deferiprone. NMR Biomed [Content Brief]

[2]. Oded Shalev. et al. Deferiprone (L1) Chelates Pathologic Iron Deposits From Membranes of Intact Thalassemic and Sickle Red Blood Cells Both In Vitro and In Vivo. [Content Brief]

[3]. Ngan Thi Tran, et al. Antiplatelet activity of deferiprone through cyclooxygenase-1 inhibition. Platelets 2020 May 18;31(4):505-512. [Content Brief]

[4]. Andrea Pagani, MD, et al. Deferiprone Stimulates Aged Dermal Fibroblasts via HIF-1α Modulation.Pathog Dis. 2018 Jul 1;76(5). [Content Brief]

[5]. Débora C Coraça-Huber, et al. Iron chelation destabilizes bacterial biofilms and potentiates the antimicrobial activity of antibiotics against coagulase-negative Staphylococci. Pathogens and Disease, Volume 76, Issue 5, July 2018, fty052 [Content Brief]

[6]. Shalini S. Rao, et al. Deferiprone Treatment in Aged Transgenic Tau Mice Improves Y-Maze Performance and Alters Tau Pathology. Neurotherapeutics. 2021 Apr;18(2):1081-1094. [Content Brief]

[7]. Makhdoumi P, et al. Oral deferiprone administration ameliorates cisplatin-induced nephrotoxicity in rats.J Pharm Pharmacol. 2018 Oct;70(10):1357-1368. [Content Brief]

[8]. Yanan Zhang, et al. Taurine and deferiprone against Al-linked apoptosis in rat hippocampus. J Trace Elem Med Biol. 2023 Mar;76:127113. [Content Brief]

[9]. Kontoghiorghes GJ, et al. Benefits and risks of deferiprone in iron overload in Thalassaemia and other conditions: comparison of epidemiological and therapeutic aspects with deferoxamine. Drug Saf. 2003;26(8):553-584. [Content Brief]

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