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MedChemExpress - Model Trimebutine maleate - 34140-59-5

Trimebutine maleate is an orally anti-tumor agent. Trimebutine maleate selectively suppresses stemness and proliferation of ovarian cancer stem cells (CSCs). Trimebutine maleate reduces the colonic muscle hypercontractility, modulates gastrointestinal motility, induces apoptosis and can be used for the research of glioma/glioblastoma and irritable bowel syndrome[1][2][3][4][5][6].

Trimebutine maleate

MCE China：Trimebutine maleate

Brand：MedChemExpress (MCE)

Cat. No.HY-B0380A

CAS：34140-59-5

Purity：99.91%

Storage：4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Trimebutine maleate is an orally anti-tumor agent. Trimebutine maleate selectively suppresses stemness and proliferation of ovarian cancer stem cells (CSCs). Trimebutine maleate reduces the colonic muscle hypercontractility, modulates gastrointestinal motility, induces apoptosis and can be used for the research of glioma/glioblastoma and irritable bowel syndrome.

In Vitro：Trimebutine maleate (1-20 μM, 60 h) dose-dependently inhibits A2780-SP cell growth [2]. Trimebutine maleate (1-10 μM, 24 h) decreases the stem cell properties of A2780-SP cells through simultaneous inhibition of the calcium and BKCa channels[2]. Trimebutine maleate (10-200 μM, 24-72 h) inhibits the cell viability, cell migration, and the ERK and AKT Signaling Pathways of glioma/glioblastoma cells [3].

In Vivo：Trimebutine maleate (25-50 mg/kg Oral, single dose) reduces the response to colorectal distension in C57Bl6 male mice[4].

References：

[1]. Long Y, et al. Effectiveness of trimebutine maleate on modulating intestinal hypercontractility in a mouse model of postinfectious irritable bowel syndrome [J]. European Journal of Pharmacology, 2010, 636(1-3): 159-165.

[2]. Lee H, et al. Repositioning trimebutine maleate as a cancer treatment targeting ovarian cancer stem cells [J]. Cells, 2021, 10(4): 918.

[3]. Fan Y, et al. Trimebutine promotes glioma cell apoptosis as a potential anti-tumor agent [J]. Frontiers in Pharmacology, 2018, 9: 664.

[4]. Cenac N, et al. A novel orally administered trimebutine compound (GIC‐1001) is anti‐nociceptive and features peripheral opioid agonistic activity and hydrogen sulphide‐releasing capacity in mice [J]. European journal of pain, 2016, 20(5): 723-730.

[5]. Lee H T, Kim B J. Trimebutine as a modulator of gastrointestinal motility [J]. Archives of pharmacal research, 2011, 34(6): 861-864.

Brand introduction:
•   MCE (MedChemExpress) has a global exclusive compound library of more than 200 kinds, and we are committed to providing the most comprehensive range of high-quality small molecule active compounds for scientific research customers around the world；
•   More than 50,000 highly selective inhibitors and agonists are involved in various popular signaling pathways and disease areas；
•   The products cover a variety of recombinant proteins, peptides, commonly used kits, more PROTAC, ADC and other characteristic products, widely used in new drug research and development, life science and other scientific research projects；
•   Provide virtual screening, ion channel screening, metabolomics analysis detection analysis, drug screening and other professional technical services；
•   It has a professional experimental center and strict quality control and verification system；
•   Provide LC/MS, NMR, HPLC, chiral analysis, elemental analysis and other quality inspection reports to ensure the high purity and high quality of products；
•   The biological activity of the products has been verified by the experiments of customers in various countries；
•   A variety of top journals such as Nature, Cell, Science and pharmaceutical patents have included the scientific research results of MCE customers；
•   Our professional team tracks the latest pharmaceutical and life science research and provides you with the latest active compounds in the world；
•   It has established long-term cooperation with the world's major pharmaceutical companies and well-known scientific research institutions。