MedChemExpress -Model Glycodeoxycholic Acid -360-65-6
Glycodeoxycholic Acid is a natural product found in Streptomyces nigricans, Trypanosoma brucei and C. elegans. Glycodeoxycholic Acid induces hepatocyte necrosis and autophagy in patients with obstructive cholestasis[1][2][3].MCE products for research use only. We do not sell to patients.
Glycodeoxycholic Acid
MCE China：Glycodeoxycholic Acid
Brand：MedChemExpress (MCE)
Cat. No.HY-125731
CAS：360-65-6
Purity：99.08%
Storage：Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Shipping：Room temperature in continental US; may vary elsewhere.
Description：Glycodeoxycholic Acid is a natural product found in Streptomyces nigricans, Trypanosoma brucei and C. elegans. Glycodeoxycholic Acid induces hepatocyte necrosis and autophagy in patients with obstructive cholestasis.
In Vitro：Glycodeoxycholic Acid (200 μM, 24-48 h) induces stemness and chemotherapy resistance of hepatocellular carcinoma cells through STAT3 signaling pathway[1]. Glycodeoxycholic Acid (50 μM, pretreatment for 1 h) can eliminate UCB-induced cytochrome c oxidase inhibition, and significantly prevent oxidative stress, metabolic changes and cell death[2].
In Vivo：Glycodeoxycholic Acid (11.20 mg/kg, biliary and pancreatic duct injection) can induce acute pancreatitis in rhesus monkeys[3].
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References：
[1]. Shi C, et al. Glycochenodeoxycholic acid induces stemness and chemoresistance via the STAT3 signaling pathway in hepatocellular carcinoma cells. Aging (Albany NY). 2020 Aug 3;12(15):15546-15555. [Content Brief]
[2]. Vaz AR, et al. Bilirubin selectively inhibits cytochrome c oxidase activity and induces apoptosis in immature cortical neurons: assessment of the protective effects of glycoursodeoxycholic acid. J Neurochem. 2010 Jan;112(1):56-65. [Content Brief]
[3]. Fauzi A, et al. Role of glycodeoxycholic acid to induce acute pancreatitis in Macaca nemestrina. J Med Primatol. 2022 Jun;51(3):134-142. doi: 10.1111/jmp.12577. Epub 2022 Mar 20. PMID: 35306662; PMCID: PMC9310849. [Content Brief]
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