MCE products for research use only. We do not sell to patients.

Alpinetin

MCE China：Alpinetin

Brand：MedChemExpress (MCE)

Cat. No.HY-N0625A

CAS：36052-37-6

Purity：99.51%

Storage：Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Alpinetin is a flavonoid isolated from cardamom and possesses antitumor, antiinflammation, hepatoprotective, cardiovascular protective, lung protective, antibacterial, antiviral, neuroprotective properties. Alpinetin inhibits lipopolysaccharide (LPS)-induced inflammation, activates PPAR-γ, activates Nrf2, and inhibits TLR4 expression to protect LPS-induced renal injury.

In Vitro：Pharmacological effects of alpinetin in vitro[2] Pharmacological effects Cell lines Doses/Duration Effects/Molecular mechanisms References Anticancer activity 4T1, MCF-7 25-100 μM for 24 or 48 h caspase-9↑, caspase-3↑, PARP↑, Bax↑, Bcl-2↓ Zhang et al. (2020) Anti-inflammatory activity RAW 264.7 25 μM for 24 h; 80-240 μg/mL for 24 h TNF-α↓, IL-6↓, IL-1β↓, p-IκB↓, p-p65↓, p-ERK↓, p-p38↓, PPAR↑, DNMT3A↑ Yu et al. (2020); Huo et al. Cardiovascular protective activity THP-1, HMDMs 50-150 μg/mL for 24 h PPAR-γ↑, LXR-α↑, ABCA1↑, ABCG1↑ Jiang et al. (2015) Antimicrobial activity Helicobacter pylori for 3 days MIC (1.25 μg/mL Huang et al. (2006) Antiviral activity Respiratory syncytial virus IC50 (77.0 μM), TI (6.0) But et al. (2009) Neuroprotective activity PC12 cells 1-10 μM for 48 h AChE↑, NF68↑, NF200↑ Liu et al. (2019) Antioxidant activity UV radiation Displayed an extensive absorption in the extent of harmful UV radiation (270-390 nm) Shireen et al. (2017)

In Vivo：Pharmacological effects of alpinetin in vivo[2] Pharmacological effects Model Doses/Duration Effects/Molecular mechanisms References Anticancer activity MDA-MB-231 100 mg/kg, i.p., tiw, for 28 days caspase-3↑, PARP↑, Bax↑, Bcl-2↓, p-p65↓, p-IκBα↓ Zhang et al. (2020) Anti-inflammatory activity LPS-induced mouse mastitis 50-1000 μg/mL for 24 h; 10-50 mg/kg, i.p MPO↓, TNF-α↓, IL-6↓, IL-1β↓, TLR4↓, p-IκB↓, p-p65↓ Chen et al. (2013) Hepatoprotective activity LPS/D-Gal-induced mouse liver injury 12.5-50 mg/kg, i.p., 1 h before LPS/D-gal treatment ALT↓, AST↓, MDA↓, MPO↓, TNF-α↓, IL-1β↓, p-IκB↓, p-p65↓, Nrf2↑, HO-1↑ Liu et al. (2019) Cardiovascular protective activity Coronary heart disease rat model 40-160 mg/kg, i.g., daily, for 4 weeks LVEDV↓, SV↑, TG↓, TC↓, HDL-C↑, LDL-C↓, NO↑, ET-1↓, PGI2↑, TNF-α↓, MCP-1↓, ICAM1↓, p-ERK↓, p-MEK↓ Dai et al. (2021)

IC50 & Target：PPAR-γ

Hot selling product：PF-01247324  | PXYC1  | Crizanlizumab  | Margatoxin  | Clonidine  | TMB  | Mometasone furoate  | U-73343  | NSC697923  | Dehydroglyasperin C

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides

References：

[1]. Hu K, et al. Alpinetin inhibits LPS-induced inflammatory mediator response by activating PPAR-γ in THP-1-derived macrophages. Eur J Pharmacol. 2013 Dec 5;721(1-3):96-102.  [Content Brief]

[2]. Zhao G, et al. Alpinetin: A Review of Its Pharmacology and Pharmacokinetics. Front Pharmacol. 2022 Feb 4;13:814370.  [Content Brief]

[3]. Gul S, et al. Alpinetin: a Dietary Flavonoid with Diverse Anticancer Effects. Appl Biochem Biotechnol. 2022 Sep;194(9):4220-4243.  [Content Brief]

[4]. Liang Y, et al. Alpinetin ameliorates inflammatory response in LPS-induced endometritis in mice. Int Immunopharmacol. 2018 Sep;62:309-312.  [Content Brief]