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MedChemExpress - Model Astaxanthin - ...

MedChemExpress - Model Astaxanthin - 472-61-7

Astaxanthin, the red dietary carotenoid, is an orally effective and potent antioxidant. Astaxanthin inhibits NF-κB and down-regulates VEGF in blood glucose. Astaxanthin exerts anti-cancer cell proliferation, increases apoptosis, impairs migration and invasion by activating PPARγ and reducing the expression of STAT3. Astaxanthin also has neuroprotective and anti-inflammatory activity and can be used in studies of cancer, diabetic retinopathy, cardiovascular disease, and in the coloring of animal feed[1][2][3][4][5].

Astaxanthin

MCE China：Astaxanthin

Brand：MedChemExpress (MCE)

Cat. No.HY-B2163

CAS：472-61-7

Purity：98.0%

Storage：-20°C, protect from light, stored under nitrogen *The compound is unstable in solutions, freshly prepared is recommended.

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Astaxanthin, the red dietary carotenoid, is an orally effective and potent antioxidant. Astaxanthin inhibits NF-κB and down-regulates VEGF in blood glucose. Astaxanthin exerts anti-cancer cell proliferation, increases apoptosis, impairs migration and invasion by activating PPARγ and reducing the expression of STAT3. Astaxanthin also has neuroprotective and anti-inflammatory activity and can be used in studies of cancer, diabetic retinopathy, cardiovascular disease, and in the coloring of animal feed.

In Vitro：Astaxanthin (50, 100, 150, 200 μM; 48 h) inhibits the proliferation of DU145 cells (IC50[1]. Astaxanthin (200 μM; 24 h) reduces the expression of STAT3 and the related pathway proteins (at both protein and mRNA levels) by inhibiting proliferation, increasing apoptosis and weakening migration and invasion[1] Astaxanthin protects RPE cells from abnormal activation and oxidative stress (induced by high glucose) by down-regulating VEGF in high glucose at protein levels[2]. Astaxanthin (1-50 μM; 72 h) upregulates protein expression of PPARγ in time- and dose-dependent manners in K562 cells[3].

In Vivo：Astaxanthin (200 mg/kg; intragastric administration; once daily for 3 weeks) inhibits the growth of DU145 tumor xenografts in nude mice[1]. Astaxanthin (125 or 500 mg/kg; in animal feedings; 7 days) provides significant cardioprotection and reduces oxidative stress in rats[4].

IC50 & Target：PPARγ STAT3

References：

[1]. Sun SQ, et al. Anti-Tumor Effects of Astaxanthin by Inhibition of the Expression of STAT3 in Prostate Cancer. Mar Drugs. 2020 Aug 7;18(8):415. [Content Brief]

[2]. Fu D, et al. Effect of astaxanthin on retinal pigment epithelial cells in high glucose: an in-vitro study. Biomed Res, 2017, 28(15): 6839-6843.

[3]. Zhang X, et al. Carotenoids inhibit proliferation and regulate expression of peroxisome proliferators-activated receptor gamma (PPARγ) in K562 cancer cells. Arch Biochem Biophys. 2011 Aug 1;512(1):96-106. [Content Brief]

[4]. Gross GJ, et al. Seven day oral supplementation with Cardax (disodium disuccinate astaxanthin) provides significant cardioprotection and reduces oxidative stress in rats. Mol Cell Biochem. 2006 Feb;283(1-2):23-30. [Content Brief]

[5]. Zhang L, et al. Multiple Mechanisms of Anti-Cancer Effects Exerted by Astaxanthin. Mar Drugs. 2015 Jul 14;13(7):4310-30. [Content Brief]

Brand introduction:
•   MCE (MedChemExpress) has a global exclusive compound library of more than 200 kinds, and we are committed to providing the most comprehensive range of high-quality small molecule active compounds for scientific research customers around the world；
•   More than 50,000 highly selective inhibitors and agonists are involved in various popular signaling pathways and disease areas；
•   The products cover a variety of recombinant proteins, peptides, commonly used kits, more PROTAC, ADC and other characteristic products, widely used in new drug research and development, life science and other scientific research projects；
•   Provide virtual screening, ion channel screening, metabolomics analysis detection analysis, drug screening and other professional technical services；
•   It has a professional experimental center and strict quality control and verification system；
•   Provide LC/MS, NMR, HPLC, chiral analysis, elemental analysis and other quality inspection reports to ensure the high purity and high quality of products；
•   The biological activity of the products has been verified by the experiments of customers in various countries；
•   A variety of top journals such as Nature, Cell, Science and pharmaceutical patents have included the scientific research results of MCE customers；
•   Our professional team tracks the latest pharmaceutical and life science research and provides you with the latest active compounds in the world；
•   It has established long-term cooperation with the world's major pharmaceutical companies and well-known scientific research institutions。