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Beta-Eudesmol

MCE China：Beta-Eudesmol

Brand：MedChemExpress (MCE)

Cat. No.HY-N6018

CAS：473-15-4

Purity：99.49%

Storage：-20°C, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Beta-Eudesmol has anticancer and anti-inflammatory activities. Beta-Eudesmol can induce apoptosis. Beta-Eudesmol is a neostigmine antagonist. Beta-Eudesmol can antagonize neostigmine-induced neuromuscular failure. Beta-Eudesmol can be used in the study of sepsis diseases. Beta-Eudesmol is a sesquiterpene-like compound that can be extracted from the rhizome of Atractylodes lancea.

In Vitro：Beta-Eudesmol (30-100 μM; 6 days) can inhibit the cell proliferation induced by vascular endothelial growth factor (VEGF) (30 ng/ml) and basic fibroblast growth factor (bFGF) (30 ng/ml) in HUVEC cells, thereby inhibiting angiogenesis[1]. Beta-Eudesmol (10-100 μM; 72 h) inhibits cell proliferation in a time- and dose-dependent manner in tumor in tumer cells HeLa, SGC-7901 and BEL-7402[1]. Beta-Eudesmol (10-120 μM; 4 h) can reduce cell activity in HL-60 cells[4]. Beta-Eudesmol (40-80 μM; 4 h) can activate caspase-3 by inducing the release of cytochrome c, thereby inducing cell apoptosis in HL-60 cells[4].

In Vivo：Beta-Eudesmol (2.5-5 mg/kg; Intraperitoneal injection; Once daily for 7 days) significantly inhibits tumor cell and new blood vessel generation in MK mice[1]. Beta-Eudesmol (50-100 mg/kg; Intraperitoneal injection; Single dose) can inhibit the NF-κb signaling pathway and has anti-inflammatory and antioxidant effects in C57BL/6 mice[2].

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References：

[1]. Ma EL,et al. Beta-eudesmol suppresses tumour growth through inhibition of tumour neovascularisation and tumour cell proliferation. J Asian Nat Prod Res. 2008 Jan-Feb;10(1-2):159-67.  [Content Brief]

[2]. Xu Q, et al. Protective effects of β-eudesmol against septic liver injury via inhibition of NF-κB signaling[J]. Tropical Journal of Pharmaceutical Research, 2022, 21(6): 1183-1188.

[3]. Chiou LC, et al. Antagonism by beta-eudesmol of neostigmine-induced neuromuscular failure in mouse diaphragms. Eur J Pharmacol. 1992 Jun 5;216(2):199-206.  [Content Brief]

[4]. Hoang D M, et al. Eudesmols induce apoptosis through release of cytochrome c in HL-60 cells[J]. Natural Product Sciences, 2010, 16(2): 88-92.