MedChemExpress -Model Rhein -478-43-3

FromMedChemExpress LLC (MCE)

Rhein is an anthraquinone compound with anti-inflammatory, antioxidant, and anti-cancer effects[1].

Rhein

MCE China：Rhein

Brand：MedChemExpress (MCE)

Cat. No.HY-N0105

CAS：478-43-3

Synonyms：Rheic Acid; Rhubarb yellow; Monorhein

Purity：99.56%

Storage：Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Rhein is an anthraquinone compound with anti-inflammatory, antioxidant, and anti-cancer effects[1].

In Vitro：Rhein (0-80 μM, 72 h) inhibits the viability of NB4 cells in a dose-dependent manner[2]. Rhein (5 μM, 72 h) increases semi-adherent, macrophage-like cells, and expression of CD11b, CD14, CCR-1 and CCR-2, and increases ROS production and phagocytosis in ATRA-activated NB4 cells[2]. Rhein (5 μM, 72 h) induces NB4 cell death by activating apoptosis and inhibiting the mTOR pathway_x000D_[2]. Rhein (50-200 μM, 48 h) inhibits angiogenesis in MCF-7 and MDA-MB-435 cells[4]. Rhein (0-50 μM, 24 h) inhibits HUVEC roliferation, migration, invasion, and tube formation (inhibits VEGF165, EGF in supernatant and HIF-1α in nuclear extract)[4].

In Vivo：Rhein (10-40 mg/kg, i.g.) protects against Acetaminophen (HY-66005)-induced hepatic and renal toxicity in rats[3].

References：

[1]. Hou ML, et al. The Drug-Drug Effects of Rhein on the Pharmacokinetics and Pharmacodynamics of Clozapine in Rat Brain Extracellular Fluid by In Vivo Microdialysis. J Pharmacol Exp Ther. 2015 Oct;355(1):125-34. [Content Brief]

[2]. Heo SK, et al. Rhein augments ATRA-induced differentiation of acute promyelocytic leukemia cells. Phytomedicine. 2018 Oct 1;49:66-74. [Content Brief]

[3]. Zhao YL, et al. Rhein protects against acetaminophen-induced hepatic and renal toxicity. Food Chem Toxicol. 2011 Aug;49(8):1705-10. [Content Brief]

[4]. Fernand VE, et al. Rhein inhibits angiogenesis and the viability of hormone-dependent and -independent cancer cells under normoxic or hypoxic conditions in vitro. Chem Biol Interact. 2011 Jul 15;192(3):220-32. [Content Brief]

Brand introduction:
•   MCE (MedChemExpress) has a global exclusive compound library of more than 200 kinds, and we are committed to providing the most comprehensive range of high-quality small molecule active compounds for scientific research customers around the world；
•   More than 50,000 highly selective inhibitors and agonists are involved in various popular signaling pathways and disease areas；
•   The products cover a variety of recombinant proteins, peptides, commonly used kits, more PROTAC, ADC and other characteristic products, widely used in new drug research and development, life science and other scientific research projects；
•   Provide virtual screening, ion channel screening, metabolomics analysis detection analysis, drug screening and other professional technical services；
•   It has a professional experimental center and strict quality control and verification system；
•   Provide LC/MS, NMR, HPLC, chiral analysis, elemental analysis and other quality inspection reports to ensure the high purity and high quality of products；
•   The biological activity of the products has been verified by the experiments of customers in various countries；
•   A variety of top journals such as Nature, Cell, Science and pharmaceutical patents have included the scientific research results of MCE customers；
•   Our professional team tracks the latest pharmaceutical and life science research and provides you with the latest active compounds in the world；
•   It has established long-term cooperation with the world's major pharmaceutical companies and well-known scientific research institutions。