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Morin

MCE China：Morin

Brand：MedChemExpress (MCE)

Cat. No.HY-N0621

CAS：480-16-0

Purity：97.02%

Storage：Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Morin is an orally active plant-derived flavonoid. Morin inhibits ROS generation. Morin induces Apoptosis. Morin inhibits PTP1B (IC50 of 15 μM) and activates the insulin receptor. Morin has a detoxifying effect. Morin can be used in diabetes, leukemia, colon cancer, cervical cancer, Parkinson's disease and hypertension research.

In Vitro：Morin (25 μM, 1 h) protects V79-4 cells from hydrogen peroxide-induced damage by inhibiting ROS generation and by inducing catalase activation[3]. Morin (100-500 μM, 6-48 h) inhibits the growth of human leukemia HL-60 cells via cell cycle arrest and induction of apoptosis through mitochondria dependent pathway[4]. Morin (50 μM, 0-70 h) inhibits growth and activates the insulin metabolic pathway in HepG2 cells[5]. Morin (100-500 μM, 48 h) shows anti-cancerous activity against HeLa cells at an IC50 of 214.28 μM and causes morphological changes[6]. Morin (5-50 μM, 24 h) exerts neuroprotective actions in PC12 cells, with attenuating loss of cell viability[7].

In Vivo：Morin (5-100 mg/kg, i.p., daily, 5 days) exerts neuroprotective actions in Parkinson disease mice[7]. Morin (10-150 mg/kg, i.p., 30 min prior to γ-irradiation) shows anticlastogenic activity against whole body gamma irradiation in Swiss albino mice[8]. Morin (100 mg/kg, intragastrically, 10 days) exacerbates Cyclophosphamide (HY-17420)-induced suppression of body weight gain in rats[9]. Morin (Morin hydrate form, 100 mg/kg, p.o., 10 days) attenuates Doxorubicin (HY-15142A)-induced heart and brain damage by reducing oxidative stress, inflammation and apoptosis in rats[10]. Morin (50 mg/kg, p.o., everyday for a total period of 30 weeks) could exert a significant chemopreventive effect on colon carcinogenesis induced by DMH in rats[11]. Morin (25-75 mg/kg, p.o., 6 weeks) exhibits strong antihypertensive effect against DOCA-salt induced hypertension in rats[12].

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References：

[1]. Duthie G, et al. Antioxidant capacity of flavonoids in hepatic microsomes is not reflected by antioxidant effects in vivo. Oxid Med Cell Longev. 2012;2012:165127.  [Content Brief]

[2]. Lian HZ, et al. Morin applied in speciation of aluminium in natural waters and biological samples by reversed-phase high-performance liquid chromatography with fluorescence detection. Anal Bioanal Chem. 2003 Jun;376(4):542-8. Epub 2003 May 9.  [Content Brief]

[3]. Zhang R, et al. Cellular protection of morin against the oxidative stress induced by hydrogen peroxide. Chem Biol Interact. 2009 Jan 15;177(1):21-7.  [Content Brief]

[4]. Kuo HM, et al. Morin inhibits the growth of human leukemia HL-60 cells via cell cycle arrest and induction of apoptosis through mitochondria dependent pathway. Anticancer Res. 2007 Jan-Feb;27(1A):395-405.  [Content Brief]

[5]. Paoli P, et al. The insulin-mimetic effect of Morin: a promising molecule in diabetes treatment. Biochim Biophys Acta. 2013 Apr;1830(4):3102-11.  [Content Brief]

[6]. Zhang Q, et al. Molecular mechanism of anti-cancerous potential of Morin extracted from mulberry in Hela cells. Food Chem Toxicol. 2018 Feb;112:466-475.  [Content Brief]

[7]. Zhang ZT, et al. Morin exerts neuroprotective actions in Parkinson disease models in vitro and in vivo. Acta Pharmacol Sin. 2010 Aug;31(8):900-6.  [Content Brief]

[8]. Parihar VK, et al. Anticlastogenic activity of morin against whole body gamma irradiation in Swiss albino mice. Eur J Pharmacol. 2007 Feb 14;557(1):58-65.  [Content Brief]

[9]. Merwid-Ląd A, et al. The effects of morin, a naturally occurring flavonoid, on cyclophosphamide-induced toxicity in rats. Advances in Clinical and Experimental Medicine, 2011, 20(6): 683-690.

[10]. Kuzu M, et al. Morin attenuates doxorubicin-induced heart and brain damage by reducing oxidative stress, inflammation and apoptosis. Biomed Pharmacother. 2018 Oct;106:443-453.  [Content Brief]

[11]. Sreedharan V, et al. Effect of morin on tissue lipid peroxidation and antioxidant status in 1, 2-dimethylhydrazine induced experimental colon carcinogenesis. Invest New Drugs. 2009 Feb;27(1):21-30.  [Content Brief]

[12]. Prahalathan P, et al. Effect of morin, a flavonoid against DOCA-salt hypertensive rats: a dose dependent study. Asian Pac J Trop Biomed. 2012 Jun;2(6):443-8.  [Content Brief]