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MedChemExpressModel Heptadecanoic acid - 506-12-7

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Heptadecanoic acid is an odd-chain saturated fatty acid (OCS-FA) with oral activity. Heptadecanoic acid can inhibit cell proliferation and induce Apoptosis. Heptadecanoic acid has antitumor activity. Heptadecanoic acid is associated with a number of diseases, including coronary heart disease, pre-diabetes and type 2 diabetes, and multiple sclerosis[1].
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Heptadecanoic acid

MCE China:Heptadecanoic acid

Brand:MedChemExpress (MCE)

Cat. No.HY-W004284

CAS:506-12-7

Purity:98.0%

Storage:Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month

Shipping:Room temperature in continental US; may vary elsewhere.

Description:Heptadecanoic acid is an odd-chain saturated fatty acid (OCS-FA) with oral activity. Heptadecanoic acid can inhibit cell proliferation and induce Apoptosis. Heptadecanoic acid has antitumor activity. Heptadecanoic acid is associated with a number of diseases, including coronary heart disease, pre-diabetes and type 2 diabetes, and multiple sclerosis.

In Vitro:Heptadecanoic acid (100 μM, 48 h) significantly inhibits the proliferation and migration of PC-9 and PC-9 /GR cells and promotes apoptosis by activating the PI3K/Akt signaling pathway[1].

In Vivo:Heptadecanoic acid (5 mg/kg orally, 10-14 days) significantly increases the frequency of defecation in rats[2].

IC50 & Target:Human Endogenous Metabolite

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References:

[1]. Changzhi Xu, et al. Heptadecanoic acid inhibits cell proliferation in PC‑9 non‑small‑cell lung cancer cells with acquired gefitinib resistancey. Oncol Rep. 2019 Jun;41(6):3499-3507.  [Content Brief]

[2]. Zhao L, et al. Saturated long-chain fatty acid-producing bacteria contribute to enhanced colonic motility in rats. Microbiome. 2018 Jun 14;6(1):107.  [Content Brief]

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