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Histamine

MCE China：Histamine

Brand：MedChemExpress (MCE)

Cat. No.HY-B1204

CAS：51-45-6

Synonyms：Ergamine

Purity：99.99%

Storage：-20°C, stored under nitrogen, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Histamine is an organic nitrogen compound that participates in local immune responses, regulates intestinal physiological functions, and acts as a neurotransmitter.

In Vivo：Histamine can be used in animal modeling to create gastrointestinal ulcer models. After intravenous injection, the maximum concentration and AUC of histamine in liver and liver tumor tissues are higher than those in subcutaneous tissues[1]. .f12{ font-size: 12px; } .fwb{ font-weight: bold; } .lh22{ line-height: 22px;; } .lh23 { line-height: 23px; } .pl13{ padding-left: 13px;; } .part { margin-top: 18px; } .mold-first-tit { width: 100%; height: 44px; line-height: 44px; background: #F9F7FB; border-bottom: 1px solid #EBE4F6; padding-left: 16px; box-sizing: border-box; margin-bottom: 17px; } .mold-second-tit:before { content:""; width: 6px; height: 6px; display: inline-block; border-radius: 50%; background: rgba(255,102,0,0.4); margin-right: 12px; position: relative; top: -3px; } .lft-border { border-left: 1px dotted #EBE4F6; padding-right: 12px; margin-left: 3px; box-sizing: border-box; padding-bottom: 12px; } /* .part .dec:last-child { border-bottom: 0; } */ .dec { margin: 10px 15px 0; padding-bottom: 10px; border-bottom: 1px dashed #EBE4F6; } .btm-border { border-left: 1px dashed #EBE4F6; } .text-bg { margin-top: 10px; background: #FFFBF1; padding: 14px; border-bottom: 0; position: relative; } .text-note-bg { margin-top: 10px; background: #FFFDF7; padding: 12px; border-bottom: 0; position: relative; } .text-note { width: 51px; height: 20px; line-height: 20px; background: #FFE2AA; text-align: center; border-radius: 0 0 8px 0; position: absolute; top: 0; left: 0; } .text-note-dec { margin-top: 15px;; } Induction of Gastrointestinal Ulcer[2] Background Histamine can cause increased gastric acid secretion, decreased mucus production, reflux of pancreatic juice, poor gastric blood flow, and thus gastric ulcers. Stress can cause increased gastrointestinal motility, making the gastric folds more susceptible to damage when exposed to acid. Specific Mmodeling Methods Guinea Pig: male • albino • Administration: 5 mg/kg • i.p. • single dose Note (1) No eating or drinking is allowed 24 hours before the experiment.(2) The animals are sacrificed 2 hours after histamine injection, and treated with 1% formalin to check for gastric ulcers. Modeling Indicators The ulcers were punctate or elongated. After the model was dissected, the ulcer index (the sum of the lengths of the lesions) was measured under a microscope to be 3.4 mm. Correlated Product(s): Serotonin (HY-B1473A); Reserpine (HY-N0480) Opposite Product(s): Cimetidine (HY-14289)

IC50 & Target：Human Endogenous Metabolite

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References：

[1]. Rizell M, Naredi P, Lindnér P, Hellstrand K, Sarno M, Jansson PA. Histamine pharmacokinetics in tumor and host tissues after bolus-dose administration in the rat. Life Sci. 2002 Jan 11;70(8):969-76.  [Content Brief]

[2]. Okabe S, et al. Effects of cimetidine, a histamine H2-receptor antagonist, on various experimental gastric and duodenal ulcers. Am J Dig Dis. 1977 Aug;22(8):677-84.  [Content Brief]