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MedChemExpress - Model Angelicin - ...

MedChemExpress - Model Angelicin - 523-50-2

Angelicin is a furanocoumarin compound that functions as an inhibitor of NF-κB and MAPK signaling pathways, exhibiting anti-inflammatory, antiviral, and antitumor activities. It suppresses the lytic replication of γ-herpesviruses, such as MHV-68, early during viral infection, potentially inhibiting RTA gene expression (IC50=28.95 μM). Angelicin also mitigates inflammation by inhibiting the phosphorylation and nuclear translocation of NF-κB, and the phosphorylation of p38 and JNK. Furthermore, it induces apoptosis in neuroblastoma cells by downregulating anti-apoptotic proteins like Bcl-2, Bcl-xL, and Mcl-1, while activating caspase-9 and caspase-3.

Angelicin

MCE China：Angelicin

Brand：MedChemExpress (MCE)

Cat. No.HY-N0763

CAS：523-50-2

Synonyms：Isopsoralen

Purity：99.98%

Storage：Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Angelicin is a furanocoumarin compound that functions as an inhibitor of NF-κB and MAPK signaling pathways, exhibiting anti-inflammatory, antiviral, and antitumor activities. It suppresses the lytic replication of γ-herpesviruses, such as MHV-68, early during viral infection, potentially inhibiting RTA gene expression (IC50=28.95 μM). Angelicin also mitigates inflammation by inhibiting the phosphorylation and nuclear translocation of NF-κB, and the phosphorylation of p38 and JNK. Furthermore, it induces apoptosis in neuroblastoma cells by downregulating anti-apoptotic proteins like Bcl-2, Bcl-xL, and Mcl-1, while activating caspase-9 and caspase-3.

In Vitro：Angelicin (30-50 μM; 48 h) induced apoptosis in SH-SY5Y cells, causing downregulation of Bcl-2, Bcl-xL, and Mcl-1 protein expression, and activated the cleavage of caspase-9 and caspase-3, leading to apoptosis[1]. Angelicin (28.95 μM; 48 h) inhibited viral replication in MHV-68-infected BHK21 cells, causing downregulation of viral proteins ORF45 and ORF65 expression, and reduced viral genome replication and RTA mRNA expression[2].

In Vivo：Angelicin (1, 5, 10 mg/kg; intraperitoneal injection; once, 1 hour before LPS induction) shows anti-inflammatory effects in the LPS-induced acute lung injury model in mice, reducing inflammatory cell infiltration and cytokine production by inhibiting the MAPK and NF-κB pathways[3].

IC50 & Target：Caspase-9 Caspase-3

References：

[1]. Rahman MA, et al. Angelicin induces apoptosis through intrinsic caspase-dependent pathway in human SH-SY5Y neuroblastoma cells. Mol Cell Biochem. 2012 Oct;369(1-2):95-104. [Content Brief]

[2]. Cho HJ, et al. Antiviral activity of angelicin against gammaherpesviruses. Antiviral Res. 2013 Oct;100(1):75-83. [Content Brief]

[3]. Liu F, et al. Angelicin regulates LPS-induced inflammation via inhibiting MAPK/NF-κB pathways. J Surg Res. 2013 Nov;185(1):300-9. [Content Brief]

Brand introduction:
•   MCE (MedChemExpress) has a global exclusive compound library of more than 200 kinds, and we are committed to providing the most comprehensive range of high-quality small molecule active compounds for scientific research customers around the world；
•   More than 50,000 highly selective inhibitors and agonists are involved in various popular signaling pathways and disease areas；
•   The products cover a variety of recombinant proteins, peptides, commonly used kits, more PROTAC, ADC and other characteristic products, widely used in new drug research and development, life science and other scientific research projects；
•   Provide virtual screening, ion channel screening, metabolomics analysis detection analysis, drug screening and other professional technical services；
•   It has a professional experimental center and strict quality control and verification system；
•   Provide LC/MS, NMR, HPLC, chiral analysis, elemental analysis and other quality inspection reports to ensure the high purity and high quality of products；
•   The biological activity of the products has been verified by the experiments of customers in various countries；
•   A variety of top journals such as Nature, Cell, Science and pharmaceutical patents have included the scientific research results of MCE customers；
•   Our professional team tracks the latest pharmaceutical and life science research and provides you with the latest active compounds in the world；
•   It has established long-term cooperation with the world's major pharmaceutical companies and well-known scientific research institutions。