Companies
MedChemExpress LLC (MCE)
Products
MedChemExpress - Model Pinaverium ...

MedChemExpress - Model Pinaverium bromide - 53251-94-8

Pinaverium bromide is an L-type calcium channel blocker with selectivity for the gastrointestinal tract, effectively relieves pain, diarrhea and intestinal discomfort, provides good therapeutic efficacies without significant adverse effects on Irritable bowel syndrome (IBS) patients[1].

Pinaverium bromide

MCE China：Pinaverium bromide

Brand：MedChemExpress (MCE)

Cat. No.HY-111613

CAS：53251-94-8

Purity：99.73%

Storage：-20°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Pinaverium bromide is an L-type calcium channel blocker with selectivity for the gastrointestinal tract, effectively relieves pain, diarrhea and intestinal discomfort, provides good therapeutic efficacies without significant adverse effects on Irritable bowel syndrome (IBS) patients.

In Vitro：Pinaverium bromide (0-30 μM, 24 h) inhibits GM-CSF or CXCL1/CXCL2 induced neutrophil migration, and inhibits ROS production in the presence of 0.1 ng/mL GM-CSF in purified neutrophils from mouse bone marrow[2]. Pinaverium bromide (3 μM, 16 h) inhibits the GM-CSF induced expression of cytokines (IL-1β, IL-6, and TNF-α) in primed neutrophils from mouse bone marrow[2]. Pinaverium bromide inhibits the contractile response to ACh or KCl in the control or stressed colonic circular muscle, with IC50s of 1.66 and 0.91 μM respectively[3].

In Vivo：Pinaverium bromide (1-10 mg/kg, i.p.) inhibits excessive systemic inflammation in Lipopolysaccharide (HY-D1056)-induced mice[2].

IC50 & Target：L-type calcium channel

References：

[1]. Dai Y, et al. Effect of pinaverium bromide on stress-induced colonic smooth muscle contractility disorder in rats. World J Gastroenterol. 2003 Mar;9(3):557-61. [Content Brief]

[2]. Chen X, et al. Pinaverium Bromide Attenuates Lipopolysaccharide-Induced Excessive Systemic Inflammation via Inhibiting Neutrophil Priming. J Immunol. 2021 Apr 15;206(8):1858-1865. [Content Brief]

[3]. Dai Y, et al. Effect of pinaverium bromide on stress-induced colonic smooth muscle contractility disorder in rats. World J Gastroenterol. 2003 Mar;9(3):557-61. [Content Brief]

Brand introduction:
•   MCE (MedChemExpress) has a global exclusive compound library of more than 200 kinds, and we are committed to providing the most comprehensive range of high-quality small molecule active compounds for scientific research customers around the world；
•   More than 50,000 highly selective inhibitors and agonists are involved in various popular signaling pathways and disease areas；
•   The products cover a variety of recombinant proteins, peptides, commonly used kits, more PROTAC, ADC and other characteristic products, widely used in new drug research and development, life science and other scientific research projects；
•   Provide virtual screening, ion channel screening, metabolomics analysis detection analysis, drug screening and other professional technical services；
•   It has a professional experimental center and strict quality control and verification system；
•   Provide LC/MS, NMR, HPLC, chiral analysis, elemental analysis and other quality inspection reports to ensure the high purity and high quality of products；
•   The biological activity of the products has been verified by the experiments of customers in various countries；
•   A variety of top journals such as Nature, Cell, Science and pharmaceutical patents have included the scientific research results of MCE customers；
•   Our professional team tracks the latest pharmaceutical and life science research and provides you with the latest active compounds in the world；
•   It has established long-term cooperation with the world's major pharmaceutical companies and well-known scientific research institutions。