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MedChemExpress - Model Curdlan - ...

MedChemExpress - Model Curdlan - 54724-00-4

Curdlan is a polysaccharide found in bacteria, consisting of a glucose homopolymer with β-1,3-glycosidic linkages[1]. Curdlan can be recognized by Dectin-1 (a C-type lectin receptor), inducing immune responses in tissue mast cells and enhancing dendritic cell effects in tumor immunity. Curdlan holds potential for research in cancer and immune-inflammatory diseases[1][2][3].

Curdlan

MCE China：Curdlan

Brand：MedChemExpress (MCE)

Cat. No.HY-131166

CAS：54724-00-4

Purity：98.0%

Storage：Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Curdlan is a polysaccharide found in bacteria, consisting of a glucose homopolymer with β-1,3-glycosidic linkages. Curdlan can be recognized by Dectin-1 (a C-type lectin receptor), inducing immune responses in tissue mast cells and enhancing dendritic cell effects in tumor immunity. Curdlan holds potential for research in cancer and immune-inflammatory diseases.

In Vitro：Curdlan (10, 30, 100 μg/mL, 48 hours) activates dendritic cells by upregulating the expression of Dectin-1 and TLR4[2]. Curdlan (10, 30, 100 μg/mL, 24 hours) activates the immune effects of dendritic cells by regulating the cell cycle, enhancing dendritic cell migration ability, and increasing NO production[2]. Curdlan (50 μg/mL, 1 hour) induces tissue mast cells to modulate immune responses via the Dectin-1 receptor, stimulating their migration, synthesis of pro-inflammatory mediators, and production of ROS[3].

In Vivo：Curdlan (10 mg/kg, i.p., every two days for 14 days) significantly enhances the antitumor immune response of dendritic cells[2].

References：

[1]. Masanori Miwa, et al. Food Applications of Curdlan. Food Hydrocolloids pp 119-124.

[2]. Kim HS, et al. Curdlan activates dendritic cells through dectin-1 and toll-like receptor 4 signaling. Int Immunopharmacol. 2016 Oct;39:71-78. [Content Brief]

[3]. Żelechowska P, et al. Curdlan stimulates tissue mast cells to synthesize pro-inflammatory mediators, generate ROS, and migrate via Dectin-1 receptor. Cell Immunol. 2020 May;351:104079. [Content Brief]

Brand introduction:
•   MCE (MedChemExpress) has a global exclusive compound library of more than 200 kinds, and we are committed to providing the most comprehensive range of high-quality small molecule active compounds for scientific research customers around the world；
•   More than 50,000 highly selective inhibitors and agonists are involved in various popular signaling pathways and disease areas；
•   The products cover a variety of recombinant proteins, peptides, commonly used kits, more PROTAC, ADC and other characteristic products, widely used in new drug research and development, life science and other scientific research projects；
•   Provide virtual screening, ion channel screening, metabolomics analysis detection analysis, drug screening and other professional technical services；
•   It has a professional experimental center and strict quality control and verification system；
•   Provide LC/MS, NMR, HPLC, chiral analysis, elemental analysis and other quality inspection reports to ensure the high purity and high quality of products；
•   The biological activity of the products has been verified by the experiments of customers in various countries；
•   A variety of top journals such as Nature, Cell, Science and pharmaceutical patents have included the scientific research results of MCE customers；
•   Our professional team tracks the latest pharmaceutical and life science research and provides you with the latest active compounds in the world；
•   It has established long-term cooperation with the world's major pharmaceutical companies and well-known scientific research institutions。