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β-Amyrin

MCE China：β-Amyrin

Brand：MedChemExpress (MCE)

Cat. No.HY-N2922

CAS：559-70-6

Purity：99.58%

Storage：Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month

Shipping：Room temperature in continental US; may vary elsewhere.

Description：β-Amyrin shows effectively counteract amyloid β (Aβ)-induced impairment of long-term potentiation (LTP). β-Amyrin is a promising candidate for Alzheimer's disease (AD) research. β-Amyrin exhibits anti-inflammatory effects, protective activity against pulmonary fibrosis, and notable antibacterial capabilities. β-Amyrin is an orally active natural triterpenoid compound.

In Vitro：β-Amyrin (1-100 μM, 0-80 min) blocks Aβ-induced synaptic dysfunction in the hippocampal tissues of mice[1]. β-Amyrin (1-10 μg, 24 h 15 min) shows antioxidant activity in cultured hPBMCs (human peripheral blood mononuclear cells)[2]. β-Amyrin (5-20 μg/mL, 16-24 h) significantly inhibits PGE2 (HY-101952), IL-6 secretion and NF-κB activation dose-dependently in LPS-induced hPBMCs[2]. β-Amyrin (5 μM, 2 h) exhibits antibacterial mode of action, leading promoting apoptosis-like death in E. coli by producing ROS.

In Vivo：β-Amyrin (4 mg/kg, p.o., daily, 5 days) ameliorates object recognition memory deficit and neurogenesis impairments in the hippocampus of Aβ-induced AD model mice[1]. β-Amyrin (20-100 μg, i.p.) inhibits carrageenan-induced paw edema of rats[2]. β-Amyrin (20-80 mg/kg, i.g., daily, 5 days) has a potent efficacy in protecting against BLM-induced mice pulmonary fibrosis via suppressing inflammatory response and oxidative stress[3]. Pharmacokinetic parameters of β-Amyrin in rats β-Amyrin standard IV (group 3) β-Amyrin standard oral dose (group 2) Dose (mg kg−1) 1 3 300 (equivalent of 3mg kg−1 β-amyrin) V (ml kg−1) 1317 AUC0→24 h (min μg ml−1) 411 10.6 47.3 Cl (ml min−1 kg−1) 2.04 t1/2λZ (h) 10.2 10.3 8.3 MRT0→24 h (h) (h) 8 8.5 8.7 Cmax (ng ml−1) (h) (h) 18.7 75 tmax (h) - 3 (n = 2) or 5 (n = 1) 3 (n = 3) or 5 (n = 1) F (%) 0.86 3.83

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References：

[1]. Park HJ, et al. β-Amyrin Ameliorates Alzheimer's Disease-Like Aberrant Synaptic Plasticity in the Mouse Hippocampus. Biomol Ther (Seoul). 2019 Jul 30.  [Content Brief]

[2]. Krishnan K, et al. Anti-inflammatory potential of β-amyrin, a triterpenoid isolated from Costus igneus. Inflammopharmacology. 2014 Dec;22(6):373-85.  [Content Brief]

[3]. Cai Z, Liu J, et al. β-Amyrin ameliorates pulmonary fibrosis by inhibiting inflammatory response and oxidative stress in mice. Pak J Pharm Sci. 2023 Mar;36(2):431-436.  [Content Brief]

[4]. Han G, et al. Antibacterial Mode of Action of β-Amyrin Promotes Apoptosis-Like Death in Escherichia coli by Producing Reactive Oxygen Species. J Microbiol Biotechnol. 2022 Dec 28;32(12):1547-1552.  [Content Brief]

[5]. Ching J, et al. Quantification of α- and β-amyrin in rat plasma by gas chromatography-mass spectrometry: application to preclinical pharmacokinetic study. J Mass Spectrom. 2011 May;46(5):457-64.  [Content Brief]