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Metamizole sodium hydrate

MCE China：Metamizole sodium hydrate

Brand：MedChemExpress (MCE)

Cat. No.HY-B1279

CAS：5907-38-0

Synonyms：Dipyrone hydrate

Purity：99.89%

Storage：4°C, stored under nitrogen *The compound is unstable in solutions, freshly prepared is recommended.

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Metamizole sodium hydrate (Dipyrone) is an orally active cyclooxygenase (COX) inhibitor.. Metamizole sodium hydrate can inhibit cell proliferation and promote cell apoptosis. Metamizole sodium hydrate has anti-inflammatory and antioxidant activities. Metamizole sodium hydrate is an antipyretic, analgesic and spasmolytic agent. Metamizole sodium hydrate can be used in research to relieve a variety of pain.

In Vitro：Metamizole sodium hydrate (1 and 10 μM, 24 h) can inhibit osteoblast differentiation and thus reduce its ability to generate new bone mineralized extracellular matrix[2]. Metamizole sodium hydrate (1-500 μM, 48 h) can inhibit cell proliferation and promote apoptosis in pancreatic cancer cell lines PaTu 8988 t and Panc-1[3].

In Vivo：Metamizole sodium hydrate (500 mg/kg, intraperitoneal injection twice a day for 7 days) can reduce the development of neuropathic pain symptoms in rats[4]. Metamizole sodium hydrate (250 or 500 mg/kg, orally) can effectively relieve pain and oxidative stress induced by scalpel incision and carrageenan in rats[5].

IC50 & Target：COX[1] In Vitro Metamizole sodium hydrate (1 and 10 μM, 24 h) can inhibit osteoblast differentiation and thus reduce its ability to generate new bone mineralized extracellular matrix[2]. Metamizole sodium hydrate (1-500 μM, 48 h) can inhibit cell proliferation and promote apoptosis in pancreatic cancer cell lines PaTu 8988 t and Panc-1[3]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Metamizole sodium hydrate Related Antibodies Cell Proliferation Assay[3] Cell Line: PaTu 8988 t, Panc-1

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References：

[1]. Pierre SC, et al. Inhibition of cyclooxygenases by dipyrone. Br J Pharmacol. 2007 Jun;151(4):494-503.  [Content Brief]

[2]. De Luna-Bertos E, et al. Therapeutic doses of nonsteroidal anti-inflammatory drugs inhibit osteosarcoma MG-63 osteoblast-like cells maturation, viability, and biomineralization potential. ScientificWorldJournal. 2013 Sep 19;2013:809891.  [Content Brief]

[3]. Malsy M, et al. Effects of metamizole, MAA, and paracetamol on proliferation, apoptosis, and necrosis in the pancreatic cancer cell lines PaTu 8988 t and Panc-1. BMC Pharmacol Toxicol. 2017 Dec 6;18(1):77.  [Content Brief]

[4]. Zajaczkowska R, et al. Metamizole relieves pain by influencing cytokine levels in dorsal root ganglia in a rat model of neuropathic pain. Pharmacol Rep. 2020 Oct;72(5):1310-1322.  [Content Brief]

[5]. Ince I, Aksoy M, et al. A Comparative Investigation of the Analgesic Effects of Metamizole and Paracetamol in Rats. J Invest Surg. 2015 Jun;28(3):173-80.  [Content Brief]