MedChemExpress -Model Rose Bengal sodium -632-69-9
Rose Bengal sodium, a synthetic fluorescein derivative, is a deep red dye primarily composed of 4,5,6,7-tetrachloro-2,4,5,7-tetraiodo fluorescein. It is widely used as an ophthalmic diagnostic agent to detect dry or damaged cells on the ocular surface. Rose Bengal sodium exhibits antitumor activity and can inhibit Friend Leukemia Virus (FLV) infection through photodynamic action. Additionally, Rose Bengal sodium can inhibit Aβ aggregation through light irradiation. Rose Bengal sodium holds potential for use in cancer, viral infections, and neurodegenerative disease research[1][2][3][4][5][6].MCE products for research use only. We do not sell to patients.
Rose Bengal sodium
MCE China：Rose Bengal sodium
Brand：MedChemExpress (MCE)
Cat. No.HY-D0214
CAS：632-69-9
Purity：99.90%
Storage：RT, sealed storage, away from moisture and light In solvent -80°C 2 years -20°C 1 year
Shipping：Room temperature in continental US; may vary elsewhere.
Description：Rose Bengal sodium, a synthetic fluorescein derivative, is a deep red dye primarily composed of 4,5,6,7-tetrachloro-2,4,5,7-tetraiodo fluorescein. It is widely used as an ophthalmic diagnostic agent to detect dry or damaged cells on the ocular surface. Rose Bengal sodium exhibits antitumor activity and can inhibit Friend Leukemia Virus (FLV) infection through photodynamic action. Additionally, Rose Bengal sodium can inhibit Aβ aggregation through light irradiation. Rose Bengal sodium holds potential for use in cancer, viral infections, and neurodegenerative disease research.
In Vitro：Rose Bengal (300 µM, 48 h) exerts toxic effects on MCF-7 cells by inducing apoptosis[3]. Rose Bengal (5 µM, under light irradiation, 24 h) inhibits Aβ aggregation, likely by binding to Ab42 and preventing its conformational transition[4].
In Vivo：Rose Bengal sodium (50 µL PV-10 (10% Rose Bengal solution), IL, once a week for 14 weeks) induced tumor-specific immune responses and reduced the number of lung metastases in the B16 melanoma mouse model[5]. Rose Bengal (7-200 µg, i.p., single dose) inhibits FLV infection via photodynamic action[6].
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References：
[1]. Doughty MJ, et, al. Fluorescence characteristics of sodium fluorescein-rose bengal ophthalmic solution mixtures. Cont Lens Anterior Eye. 2014 Oct; 37(5): 358-62. [Content Brief]
[2]. Roat MI, et, al. The antiviral effects of rose bengal and fluorescein. Arch Ophthalmol. 1987 Oct; 105(10): 1415-7. [Content Brief]
[3]. Mousavi SH, et al. Direct toxicity of Rose Bengal in MCF-7 cell line: role of apoptosis. Food Chem Toxicol. 2009 Apr;47(4):855-9. [Content Brief]
[4]. Lee JS, et al. Photo-induced inhibition of Alzheimer's β-amyloid aggregation in vitro by rose bengal. Biomaterials. 2015 Jan;38:43-9. [Content Brief]
[5]. Toomey P, et al. Intralesional injection of rose bengal induces a systemic tumor-specific immune response in murine models of melanoma and breast cancer. PLoS One. 2013 Jul 17;8(7):e68561. [Content Brief]
[6]. Stevenson NR, Lenard J. Antiretroviral activities of hypericin and rose bengal: photodynamic effects on Friend leukemia virus infection of mice. Antiviral Res. 1993 Jun;21(2):119-27. [Content Brief]
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