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MedChemExpress - Model Meclofenamic acid sodium - 6385-02-0

Meclofenamic acid (Meclofenamate) sodium is a non-steroidal anti-inflammatory agent (NSAID). Meclofenamic acid sodium is a non-selective gap-junction blocker and a highly selective inhibitor of fat - and obesity-related enzyme (FTO). Meclofenamic acid sodium has anti-inflammatory and antitumor activities[1][2][3].

Meclofenamic acid sodium

MCE China：Meclofenamic acid sodium

Brand：MedChemExpress (MCE)

Cat. No.HY-B1320

CAS：6385-02-0

Synonyms：Meclofenamate sodium

Purity：99.70%

Storage：4°C, sealed storage, away from moisture and light *In solvent : -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture and light)

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Meclofenamic acid (Meclofenamate) sodium is a non-steroidal anti-inflammatory agent (NSAID). Meclofenamic acid sodium is a non-selective gap-junction blocker and a highly selective inhibitor of fat - and obesity-related enzyme (FTO). Meclofenamic acid sodium has anti-inflammatory and antitumor activities.

In Vitro：Meclofenamic acid sodium (10, 100, 200 mM, 4 days) inhibits the proliferation and migration of haSMCs[1]. Meclofenamic acid sodium (4, 6 μM, 48 h) combines with gefitinib-induced caspase-related apoptosis of resistant NSCLC cells[2].

In Vivo：Meclofenamic acid sodium (10 mg/kg/day, intraperitoneally injected for 20 days) shows antitumor activity in mouse prostate tumor model[2].

References：

[1]. Schober W, et al. Meclofenamic acid for inhibition of human vascular smooth muscle cell proliferation and migration: an in vitro study. Cardiovasc Intervent Radiol. 2002 Jan-Feb;25(1):57-63. [Content Brief]

[2]. Chen H, et al. Meclofenamic Acid Restores Gefinitib Sensitivity by Downregulating Breast Cancer Resistance Protein and Multidrug Resistance Protein 7 via FTO/m6A-Demethylation/c-Myc in Non-Small Cell Lung Cancer. Front Oncol. 2022 Apr 21;12:870636. [Content Brief]

[3]. Schrier DJ, et al. The topical anti-inflammatory effects of a topical preparation of meclofenamic acid on carrageenan-induced footpad swelling in mice. J Pharm Pharmacol. 1987 Jan;39(1):57-9. [Content Brief]

Brand introduction:
•   MCE (MedChemExpress) has a global exclusive compound library of more than 200 kinds, and we are committed to providing the most comprehensive range of high-quality small molecule active compounds for scientific research customers around the world；
•   More than 50,000 highly selective inhibitors and agonists are involved in various popular signaling pathways and disease areas；
•   The products cover a variety of recombinant proteins, peptides, commonly used kits, more PROTAC, ADC and other characteristic products, widely used in new drug research and development, life science and other scientific research projects；
•   Provide virtual screening, ion channel screening, metabolomics analysis detection analysis, drug screening and other professional technical services；
•   It has a professional experimental center and strict quality control and verification system；
•   Provide LC/MS, NMR, HPLC, chiral analysis, elemental analysis and other quality inspection reports to ensure the high purity and high quality of products；
•   The biological activity of the products has been verified by the experiments of customers in various countries；
•   A variety of top journals such as Nature, Cell, Science and pharmaceutical patents have included the scientific research results of MCE customers；
•   Our professional team tracks the latest pharmaceutical and life science research and provides you with the latest active compounds in the world；
•   It has established long-term cooperation with the world's major pharmaceutical companies and well-known scientific research institutions。