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MedChemExpress - Model Alternariol - ...

MedChemExpress - Model Alternariol - 641-38-3

Alternariol is an orally ingested mycotoxin produced by Alternaria, capable of inhibiting the activity of topoisomerase I and II (topoisomerase I, topoisomerase II). Alternariol has weak estrogenic (Estrogen Receptor/ERR) and androgen/antiandrogen (Androgen Receptor) effects. Alternariol can induce apoptosis, trigger cell cycle arrest, suppress innate immune responses, and exhibit anti-tumor activity. Alternariol has genotoxic, mutagenic, and endocrine-disrupting effects[1][2][3][4][5].

Alternariol

MCE China：Alternariol

Brand：MedChemExpress (MCE)

Cat. No.HY-N6714

CAS：641-38-3

Purity：99.55%

Storage：4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Alternariol is an orally ingested mycotoxin produced by Alternaria, capable of inhibiting the activity of topoisomerase I and II (topoisomerase I, topoisomerase II). Alternariol has weak estrogenic (Estrogen Receptor/ERR) and androgen/antiandrogen (Androgen Receptor) effects. Alternariol can induce apoptosis, trigger cell cycle arrest, suppress innate immune responses, and exhibit anti-tumor activity. Alternariol has genotoxic, mutagenic, and endocrine-disrupting effects.

In Vitro：Alternariol (10 μM, 24 h) inhibits the innate immune response of human lung epithelial cells (BEAS-2B) and mouse macrophages (RAW264.7)[2]. Alternariol (5-10 μM, 24 h) dose-dependently reduces inflammation in BEAS-2B cells induced by LPS (HY-D1056, 10 µg) [2]. Alternariol (1-100 μM, 24 h) inhibits the proliferation of BEAS-2B cells and induces cell cycle arrest[2]. Alternariol (10 μM, 24 h) induces HPRT and TK mutations in V79 cells and mouse lymphoma L5178Y tk+/− cells (MLC)[3].

In Vivo：Alternariol (1-5 mg/kg, intravenous injectionon, daily, 4 days) has embryotoxic and immunotoxic effects during the embryonic and infant developmental stages in mice, inducing apoptosis[4]. Alternariol (50-200 mg/kg, orally, once daily, 24 weeks) induces cell death and inhibits cell proliferation in DMBA (HY-W011845) induced breast cancer in mice, significantly suppressing breast cancer[5].

References：

[1]. Fliszár-Nyúl E, et al. Interaction of Mycotoxin Alternariol with Serum Albumin. Int J Mol Sci. 2019 May 12;20(9). pii: E2352. [Content Brief]

[2]. Grover S, et al. The Alternaria alternate Mycotoxin Alternariol Suppresses Lipopolysaccharide-Induced Inflammation. Int J Mol Sci. 2017 Jul 20;18(7). pii: E1577. [Content Brief]

[3]. Eva-Maria Brugger, et al. Mutagenicity of the mycotoxin alternariol in cultured mammalian cells. Toxicol Lett. 2006 Jul 14;164(3):221-30. [Content Brief]

[4]. Chien-Hsun Huang, et al. Alternariol exerts embryotoxic and immunotoxic effects on mouse blastocysts through ROS-mediated apoptotic processes. Toxicol Res (Camb). 2021 Jun 16;10(4):719-732. [Content Brief]

[5]. Jian Xin, et al. Alternariol alleviates breast carcinoma by inhibiting cellular proliferation correlated with increased apoptotic events in rats. European Journal of Inflammation.Volume 20: 1–13

Brand introduction:
•   MCE (MedChemExpress) has a global exclusive compound library of more than 200 kinds, and we are committed to providing the most comprehensive range of high-quality small molecule active compounds for scientific research customers around the world；
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•   The biological activity of the products has been verified by the experiments of customers in various countries；
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